S-substituted 2-mercaptoquinazolin-4(3H)-one and 4-ethylbenzensulfonamides act as potent and selective human carbonic anhydrase IX and XII inhibitors.

Antigens, Neoplasm / metabolism Carbonic Anhydrase IX / antagonists & inhibitors Carbonic Anhydrase Inhibitors / chemical synthesis Carbonic Anhydrases / metabolism Dose-Response Relationship, Drug Humans Isoenzymes / antagonists & inhibitors Molecular Docking Simulation Molecular Structure Quinazolinones / chemistry Structure-Activity Relationship Sulfonamides / chemistry
Metalloenzyme molecular docking study quinazolinone incorporating ethylsulfonamide selectivity CA inhibitors

Journal

Journal of enzyme inhibition and medicinal chemistry
ISSN: 1475-6374
Titre abrégé: J Enzyme Inhib Med Chem
Pays: England
ID NLM: 101150203

Informations de publication

Date de publication:
Dec 2020
Historique:
entrez: 20 3 2020
pubmed: 20 3 2020
medline: 28 10 2020
Statut: ppublish

Résumé

We evaluated the hCA (CA, EC 4.2.1.1) inhibitory activity of novel 4-(2-(2-substituted-thio-4-oxoquinazolin-3(4H)-yl)ethyl)benzenesulfonamides (compounds

Identifiants

DOI: 10.1080/14756366.2020.1742117 PMID: 32189526 PMC: PMC7144323
pubmed: 32189526
doi: 10.1080/14756366.2020.1742117
pmc: PMC7144323
doi:

Substances chimiques

Antigens, Neoplasm 0
Carbonic Anhydrase Inhibitors 0
Isoenzymes 0
Quinazolinones 0
Sulfonamides 0
CA9 protein, human EC 4.2.1.1
Carbonic Anhydrase IX EC 4.2.1.1
Carbonic Anhydrases EC 4.2.1.1
carbonic anhydrase XII EC 4.2.1.1

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

733-743

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Auteurs

Adel S El-Azab (AS)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
ORCID: 0000-0001-7197-1515

Alaa A-M Abdel-Aziz (AA)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
ORCID: 0000-0002-3362-9337

Silvia Bua (S)

Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.

Alessio Nocentini (A)

Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.

Nawaf A AlSaif (NA)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Mohammed M Alanazi (MM)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Manal A El-Gendy (MA)

Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.

Hany E A Ahmed (HEA)

Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Al-Azhar University, Cairo, Egypt.
Pharmacognosy and Pharmaceutical Chemistry Department, College of Pharmacy, Taibah University, Al-Madinah Al-Munawarah, Saudi Arabia.

Claudiu T Supuran (CT)

Department of Neurofarba, Sezione di Scienze Farmaceutiche e Nutraceutiche, Università degli Studi di Firenze, Florence, Italy.
ORCID: 0000-0003-4262-0323

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Classifications MeSH

questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Facteurs biologiques › Antigènes › Antigènes néoplasiques › Carbonic anhydrase IX › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Mécanismes moléculaires de l'action pharmacologique › Antienzymes › Inhibiteurs de l'anhydrase carbonique › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Lyases › Carbon-oxygen lyases › Hydro-lyases › Carbonic anhydrases › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes toxicologiques › Relation dose-effet des médicaments › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Isoformes de protéines › Isoenzymes › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Quinazolines › Quinazolinones › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Relation structure-activité › S-substituted 2-mercaptoquinazolin-4(3H)-one...
questionsmedicales.fr › Composés chimiques organiques › Composés du soufre › Sulfones › Sulfonamides › S-substituted 2-mercaptoquinazolin-4(3H)-one...