Sphingosine Kinase 1/S1P Signaling Contributes to Pulmonary Fibrosis by Activating Hippo/YAP Pathway and Mitochondrial Reactive Oxygen Species in Lung Fibroblasts.
Active Transport, Cell Nucleus
Adaptor Proteins, Signal Transducing
Alveolar Epithelial Cells
/ metabolism
Animals
Bleomycin
/ adverse effects
Cell Cycle Proteins
/ metabolism
Fibroblasts
/ metabolism
Fibronectins
/ genetics
Gene Deletion
Gene Expression
Hippo Signaling Pathway
Humans
Idiopathic Pulmonary Fibrosis
/ etiology
Immunohistochemistry
Lysophospholipids
/ metabolism
Methanol
/ analogs & derivatives
Mice
Mitochondria
/ metabolism
Phosphotransferases (Alcohol Group Acceptor)
/ antagonists & inhibitors
Protein Serine-Threonine Kinases
/ metabolism
Pyrrolidines
/ pharmacology
Reactive Oxygen Species
/ metabolism
Signal Transduction
Sphingosine
/ analogs & derivatives
Sulfones
Transcription Factors
/ metabolism
Transforming Growth Factor beta1
/ metabolism
YAP-Signaling Proteins
BLM
S1P
SPHK1
TGF-β
YAP signaling
lung fibroblast
pulmonary fibrosis
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
17 Mar 2020
17 Mar 2020
Historique:
received:
29
01
2020
revised:
12
03
2020
accepted:
13
03
2020
entrez:
21
3
2020
pubmed:
21
3
2020
medline:
15
12
2020
Statut:
epublish
Résumé
The sphingosine kinase 1 (SPHK1)/sphingosine-1-phosphate (S1P) signaling axis is emerging as a key player in the development of idiopathic pulmonary fibrosis (IPF) and bleomycin (BLM)-induced lung fibrosis in mice. Recent evidence implicates the involvement of the Hippo/Yes-associated protein (YAP) 1 pathway in lung diseases, including IPF, but its plausible link to the SPHK1/S1P signaling pathway is unclear. Herein, we demonstrate the increased co-localization of YAP1 with the fibroblast marker FSP1 in the lung fibroblasts of BLM-challenged mice, and the genetic deletion of
Identifiants
pubmed: 32192225
pii: ijms21062064
doi: 10.3390/ijms21062064
pmc: PMC7139883
pii:
doi:
Substances chimiques
Adaptor Proteins, Signal Transducing
0
Cell Cycle Proteins
0
Fibronectins
0
Lysophospholipids
0
PF-543
0
Pyrrolidines
0
Reactive Oxygen Species
0
Sulfones
0
Transcription Factors
0
Transforming Growth Factor beta1
0
YAP-Signaling Proteins
0
YAP1 protein, human
0
YY1AP1 protein, human
0
Bleomycin
11056-06-7
sphingosine 1-phosphate
26993-30-6
Phosphotransferases (Alcohol Group Acceptor)
EC 2.7.1.-
sphingosine kinase
EC 2.7.1.-
Protein Serine-Threonine Kinases
EC 2.7.11.1
Sphingosine
NGZ37HRE42
Methanol
Y4S76JWI15
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL060678
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL126609
Pays : United States
Organisme : NHLBI NIH HHS
ID : T32 HL007829
Pays : United States
Organisme : National Institutes of Health, HLBI
ID : P01 077806, P01 126609, R01 127342, HD 090887
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