Molecular dissection of pheromone selectivity in the competence signaling system ComRS of streptococci.
(R)RNPP
XIP pheromone
cell-to-cell communication
cross-talk
quorum sensing
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
pubmed:
22
3
2020
medline:
15
7
2020
entrez:
22
3
2020
Statut:
ppublish
Résumé
Competence allows bacteria to internalize exogenous DNA fragments for the acquisition of new phenotypes such as antibiotic resistance or virulence traits. In most streptococci, competence is regulated by ComRS signaling, a system based on the mature ComS pheromone (XIP), which is internalized to activate the (R)RNPP-type ComR sensor by triggering dimerization and DNA binding. Cross-talk analyses demonstrated major differences of selectivity between ComRS systems and raised questions concerning the mechanism of pheromone-sensor recognition and coevolution. Here, we decipher the molecular determinants of selectivity of the closely related ComRS systems from
Identifiants
pubmed: 32198205
pii: 1916085117
doi: 10.1073/pnas.1916085117
pmc: PMC7149491
doi:
Substances chimiques
Pheromones
0
Luciferases
EC 1.13.12.-
Banques de données
PDB
['6HU8', '6HUA', '6QER']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7745-7754Déclaration de conflit d'intérêts
The authors declare no competing interest.
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