Adenosine A
5-HT
Adenosine,
Antinociception
Brain
Colonic distension
Journal
Physiology & behavior
ISSN: 1873-507X
Titre abrégé: Physiol Behav
Pays: United States
ID NLM: 0151504
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
received:
21
02
2020
revised:
17
03
2020
accepted:
17
03
2020
pubmed:
23
3
2020
medline:
22
6
2021
entrez:
23
3
2020
Statut:
ppublish
Résumé
We have recently demonstrated that N(6)-cyclopentyladenosine (CPA), an adenosine A1 receptor agonist, acts centrally to induce a visceral antinociception. Since serotonin (5-HT), cannabinoid (CB), dopamine or opioid signaling in the central nervous system is involved in the regulation of visceral sensation, we made a hypothesis that the signaling may play a role in the CPA-induced visceral antinociception. Visceral sensation was evaluated by colonic distension-induced abdominal withdrawal reflex (AWR) in conscious rats. Subcutaneously administered CPA significantly increased the threshold of colonic distension-induced AWR. Intracisternal injection of either 5-HT
Identifiants
pubmed: 32199997
pii: S0031-9384(20)30198-0
doi: 10.1016/j.physbeh.2020.112881
pii:
doi:
Substances chimiques
Adenosine A1 Receptor Agonists
0
Analgesics
0
Analgesics, Opioid
0
Cannabinoids
0
Receptor, Cannabinoid, CB1
0
Receptor, Cannabinoid, CB2
0
Receptor, Serotonin, 5-HT2A
0
Receptors, Dopamine D1
0
Receptor, Serotonin, 5-HT1A
112692-38-3
Serotonin
333DO1RDJY
Dopamine
VTD58H1Z2X
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
112881Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.