Endothelin-1 Mediates the Systemic and Renal Hemodynamic Effects of GPR81 Activation.
Animals
Arteries
/ drug effects
Blood Pressure
/ drug effects
Bosentan
/ pharmacology
Endothelin-1
/ blood
Glomerular Filtration Rate
/ drug effects
Heart
/ drug effects
Hemodynamics
/ drug effects
Infusions, Intravenous
Kidney
/ blood supply
Lactates
/ blood
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Muscle, Smooth, Vascular
/ drug effects
Oligopeptides
/ pharmacology
Paracrine Communication
Peptides, Cyclic
/ pharmacology
Pericytes
/ drug effects
Piperidines
/ pharmacology
RNA, Messenger
/ biosynthesis
Receptors, G-Protein-Coupled
/ agonists
Renal Circulation
/ drug effects
Reperfusion Injury
/ blood
blood pressure
hypoxia
ischemia-reperfusion-injury
pericytes
renal blood flow
Journal
Hypertension (Dallas, Tex. : 1979)
ISSN: 1524-4563
Titre abrégé: Hypertension
Pays: United States
ID NLM: 7906255
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
pubmed:
24
3
2020
medline:
7
4
2021
entrez:
24
3
2020
Statut:
ppublish
Résumé
GPR81 (G-protein-coupled receptor 81) is highly expressed in adipocytes, and activation by the endogenous ligand lactate inhibits lipolysis. GPR81 is also expressed in the heart, liver, and kidney, but roles in nonadipose tissues are poorly defined. GPR81 agonists, developed to improve blood lipid profile, might also provide insights into GPR81 physiology. Here, we assessed the blood pressure and renal hemodynamic responses to the GPR81 agonist, AZ'5538. In male wild-type mice, intravenous AZ'5538 infusion caused a rapid and sustained increase in systolic and diastolic blood pressure. Renal artery blood flow, intrarenal tissue perfusion, and glomerular filtration rate were all significantly reduced. AZ'5538 had no effect on blood pressure or renal hemodynamics in
Identifiants
pubmed: 32200679
doi: 10.1161/HYPERTENSIONAHA.119.14308
pmc: PMC7176350
doi:
Substances chimiques
Endothelin-1
0
Hcar1 protein, mouse
0
Lactates
0
Oligopeptides
0
Peptides, Cyclic
0
Piperidines
0
RNA, Messenger
0
Receptors, G-Protein-Coupled
0
BQ 788
44OLL8XEJ4
Bosentan
Q326023R30
cyclo(Trp-Asp-Pro-Val-Leu)
S2A8YZM151
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1213-1222Subventions
Organisme : British Heart Foundation
ID : FS/15/63/32033
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/13/3/30183
Pays : United Kingdom
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