Abstinence-dependent dissociable central amygdala microcircuits control drug craving.
Animals
Behavior, Animal
Central Amygdaloid Nucleus
/ physiology
Craving
/ physiology
Disease Models, Animal
Drug-Seeking Behavior
/ physiology
Humans
Interpersonal Relations
Male
Methamphetamine
/ administration & dosage
Neurons
/ metabolism
Protein Kinase C-delta
/ genetics
RNA, Small Interfering
/ administration & dosage
Rats
Rats, Sprague-Dawley
Self Administration
Somatostatin
/ genetics
PKCδ
SOM
amygdala
social reward
voluntary abstinence
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
07 04 2020
07 04 2020
Historique:
pubmed:
25
3
2020
medline:
21
7
2020
entrez:
25
3
2020
Statut:
ppublish
Résumé
We recently reported that social choice-induced voluntary abstinence prevents incubation of methamphetamine craving in rats. This inhibitory effect was associated with activation of protein kinase-Cδ (PKCδ)-expressing neurons in central amygdala lateral division (CeL). In contrast, incubation of craving after forced abstinence was associated with activation of CeL-expressing somatostatin (SOM) neurons. Here we determined the causal role of CeL PKCδ and SOM in incubation using short-hairpin RNAs against PKCδ or SOM that we developed and validated. We injected two groups with shPKCδ or shCtrl
Identifiants
pubmed: 32205443
pii: 2001615117
doi: 10.1073/pnas.2001615117
pmc: PMC7148559
doi:
Substances chimiques
RNA, Small Interfering
0
Methamphetamine
44RAL3456C
Somatostatin
51110-01-1
Prkcd protein, rat
EC 2.7.1.-
Protein Kinase C-delta
EC 2.7.11.13
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
8126-8134Subventions
Organisme : NIAAA NIH HHS
ID : R01 AA026075
Pays : United States
Commentaires et corrections
Type : ErratumIn
Type : ErratumIn
Déclaration de conflit d'intérêts
The authors declare no competing interest.
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