Targeted Delivery of Anti-inflammatory and Imaging Agents to Microglial Cells with Polymeric Nanoparticles.
l-tyrosine polyphosphate
microglia
nanoparticles
theranostic
Journal
Molecular pharmaceutics
ISSN: 1543-8392
Titre abrégé: Mol Pharm
Pays: United States
ID NLM: 101197791
Informations de publication
Date de publication:
01 06 2020
01 06 2020
Historique:
pubmed:
28
3
2020
medline:
8
6
2021
entrez:
28
3
2020
Statut:
ppublish
Résumé
Insult to the central nervous system (CNS) results in an early inflammatory response, which can be exploited as an initial indicator of neurological dysfunction. Nanoparticle drug delivery systems provide a mechanism to increase the uptake of drugs into specific cell types in the CNS such as microglia, the resident macrophage responsible for innate immune response. In this study, we developed two nanoparticle-based carriers as potential theranostic systems for drug delivery to microglial cells. Poly(lactic-
Identifiants
pubmed: 32212701
doi: 10.1021/acs.molpharmaceut.9b00489
doi:
Substances chimiques
Anti-Inflammatory Agents
0
Organophosphates
0
Polymers
0
tyrosine polyphosphate
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM