Risk of bacteremia in hospitalised patients with inflammatory bowel disease: a 9-year cohort study.
Adolescent
Adult
Age Factors
Aged
Aged, 80 and over
Bacteremia
/ epidemiology
Colitis, Ulcerative
/ blood
Crohn Disease
/ blood
Female
Humans
Immunosuppressive Agents
/ administration & dosage
Length of Stay
/ statistics & numerical data
Male
Middle Aged
Retrospective Studies
Risk Factors
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
Young Adult
Crohn’s disease
Inflammatory bowel disease
anti-TNF
bacteremia
hospitalization
risk factors
ulcerative colitis
Journal
United European gastroenterology journal
ISSN: 2050-6414
Titre abrégé: United European Gastroenterol J
Pays: England
ID NLM: 101606807
Informations de publication
Date de publication:
03 2020
03 2020
Historique:
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
22
6
2021
Statut:
ppublish
Résumé
Patients with inflammatory bowel disease might be at increased risk of invasive bacterial infections. The objective of this study was to identify the rate of bacteremia in hospitalised patients with inflammatory bowel disease and risk factors. An observational cohort of hospitalised patients with inflammatory bowel disease, aged 16-80 years, from 2008 to 2017 in a large tertiary hospital. Patients with Charlson comorbidity index of 2 or greater were excluded. Patients with one or more positive blood culture were reviewed. Logistic regression was used to evaluate risk factors for bacteremia. Of 5522 admitted patients, only 1.3% had bacteremia (73/5522) (39, Crohn's disease; 25, ulcerative colitis; nine, unclassified inflammatory bowel disease). The most common pathogen was Age over 65 years, but not inflammatory bowel disease-related medications, is associated with an increased risk of bacteremia in hospitalised patients with inflammatory bowel disease.
Sections du résumé
BACKGROUND
Patients with inflammatory bowel disease might be at increased risk of invasive bacterial infections.
OBJECTIVES
The objective of this study was to identify the rate of bacteremia in hospitalised patients with inflammatory bowel disease and risk factors.
METHODS
An observational cohort of hospitalised patients with inflammatory bowel disease, aged 16-80 years, from 2008 to 2017 in a large tertiary hospital. Patients with Charlson comorbidity index of 2 or greater were excluded. Patients with one or more positive blood culture were reviewed. Logistic regression was used to evaluate risk factors for bacteremia.
RESULTS
Of 5522 admitted patients, only 1.3% had bacteremia (73/5522) (39, Crohn's disease; 25, ulcerative colitis; nine, unclassified inflammatory bowel disease). The most common pathogen was
CONCLUSION
Age over 65 years, but not inflammatory bowel disease-related medications, is associated with an increased risk of bacteremia in hospitalised patients with inflammatory bowel disease.
Identifiants
pubmed: 32213075
doi: 10.1177/2050640619874524
pmc: PMC7079278
doi:
Substances chimiques
Immunosuppressive Agents
0
TNF protein, human
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
195-203Références
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