Association between preoperative levels of 25-hydroxyvitamin D and hospital-acquired infections after hepatobiliary surgery: A prospective study in a third-level hospital.
Aged
Cross Infection
/ epidemiology
Digestive System Surgical Procedures
/ adverse effects
Female
Gastrointestinal Diseases
/ surgery
Hospital Mortality
Humans
Male
Middle Aged
Patient Readmission
/ statistics & numerical data
Postoperative Complications
/ epidemiology
Preoperative Period
Prospective Studies
Risk Factors
Spain
/ epidemiology
Surgical Wound Infection
Tertiary Care Centers
/ statistics & numerical data
Vitamin D
/ analogs & derivatives
Vitamin D Deficiency
/ complications
Journal
PloS one
ISSN: 1932-6203
Titre abrégé: PLoS One
Pays: United States
ID NLM: 101285081
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
01
2020
accepted:
26
02
2020
entrez:
28
3
2020
pubmed:
28
3
2020
medline:
27
6
2020
Statut:
epublish
Résumé
Evidence implicates vitamin D deficiency in poorer outcomes and increased susceptibility to hospital-acquired infections (HAIs). This study examined the association between serum vitamin D levels and HAIs in a population of hepatobiliary surgery patients. Participants in this prospective analytical observational study were patients who underwent hepatobiliary surgery in a tertiary hospital in Aragon, Spain, between February 2018 and March 2019. Vitamin D concentrations were measured at admission and all nosocomial infections during hospitalization and after discharge were recorded. The mean 25-hydroxyvitamin D concentration of the study population (n = 301) was 38.56 nmol/L, which corresponds to vitamin D deficiency. Higher vitamin D concentrations were associated with a decreased likelihood of developing a HAI in general (p = 0.014), and in particularly surgical site infection (p = 0.026). The risk of HAI decreased by 34% with each 26.2-nmol/L increase in serum vitamin D levels. Vitamin D levels may constitute a modifiable risk factor for postoperative nosocomial infections in hepatobiliary surgery patients.
Identifiants
pubmed: 32214325
doi: 10.1371/journal.pone.0230336
pii: PONE-D-20-02256
pmc: PMC7098583
doi:
Substances chimiques
Vitamin D
1406-16-2
25-hydroxyvitamin D
A288AR3C9H
Types de publication
Journal Article
Observational Study
Langues
eng
Sous-ensembles de citation
IM
Pagination
e0230336Déclaration de conflit d'intérêts
None of the authors have any conflicts of interests to disclose.
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