Hyperprolactinemia and bone.
Antipsychotic drugs
Bone density
Bone metabolism
Hyperprolactinemia
Osteoporosis
Prolactin
Vertebral fractures
Journal
Pituitary
ISSN: 1573-7403
Titre abrégé: Pituitary
Pays: United States
ID NLM: 9814578
Informations de publication
Date de publication:
Jun 2020
Jun 2020
Historique:
pubmed:
29
3
2020
medline:
2
2
2021
entrez:
29
3
2020
Statut:
ppublish
Résumé
Prolactin (PRL) has direct and indirect effects on bone metabolism. Experimental studies showed that in the presence of high PRL levels bone resorption was increased as well as bone formation was suppressed. Increased PRL levels in humans caused a reduction in sex hormone levels which turn may have detrimental effects on bone. Patients with hyperprolactinemia did have often decreased bone mineral density as well as an increased risk of fractures. Since PRL control may be relevant to bone health it is a clinical open issue the inclusion of skeletal health in future guidelines as indication to proactive screening, prevention and treatment particularly in high risk patients such as hyperprolactinemic women after menopause and patients with drug induced hyperprolactinemia.
Identifiants
pubmed: 32219718
doi: 10.1007/s11102-020-01041-3
pii: 10.1007/s11102-020-01041-3
doi:
Substances chimiques
Antipsychotic Agents
0
Prolactin
9002-62-4
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-321Références
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