MAP4K4 negatively regulates CD8 T cell-mediated antitumor and antiviral immunity.
Animals
Antigen-Presenting Cells
/ immunology
CD8-Positive T-Lymphocytes
/ immunology
Disease Models, Animal
Humans
Intracellular Signaling Peptides and Proteins
/ deficiency
Lymphocyte Function-Associated Antigen-1
/ immunology
Mice
Mice, Knockout
Mice, Transgenic
Neoplasms
/ immunology
Protein Serine-Threonine Kinases
/ deficiency
Viruses
/ immunology
Journal
Science immunology
ISSN: 2470-9468
Titre abrégé: Sci Immunol
Pays: United States
ID NLM: 101688624
Informations de publication
Date de publication:
27 03 2020
27 03 2020
Historique:
received:
30
05
2019
revised:
01
11
2019
accepted:
27
02
2020
entrez:
30
3
2020
pubmed:
30
3
2020
medline:
1
1
2021
Statut:
ppublish
Résumé
During cytotoxic T cell activation, lymphocyte function-associated antigen-1 (LFA-1) engages its ligands on antigen-presenting cells (APCs) or target cells to enhance T cell priming or lytic activity. Inhibiting LFA-1 dampens T cell-dependent symptoms in inflammation, autoimmune diseases, and graft-versus-host disease. However, the therapeutic potential of augmenting LFA-1 function is less explored. Here, we show that genetic deletion or inhibition of mitogen-activated protein kinase kinase kinase kinase 4 (MAP4K4) enhances LFA-1 activation on CD8 T cells and improves their adherence to APCs or LFA-1 ligand. In addition, loss of
Identifiants
pubmed: 32220977
pii: 5/45/eaay2245
doi: 10.1126/sciimmunol.aay2245
pii:
doi:
Substances chimiques
Intracellular Signaling Peptides and Proteins
0
Lymphocyte Function-Associated Antigen-1
0
MAP4K4 protein, human
EC 2.7.1.11
Protein Serine-Threonine Kinases
EC 2.7.11.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.