Recent advances in primary immunodeficiency: from molecular diagnosis to treatment.
hematopoietic stem cell transplantation
inborn error of immunity
next generation sequencing
primary immunodeficiency
targeted therapy
Journal
F1000Research
ISSN: 2046-1402
Titre abrégé: F1000Res
Pays: England
ID NLM: 101594320
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
16
03
2020
entrez:
1
4
2020
pubmed:
1
4
2020
medline:
19
8
2020
Statut:
epublish
Résumé
The technological advances in diagnostics and therapy of primary immunodeficiency are progressing at a fast pace. This review examines recent developments in the field of inborn errors of immunity, from their definition to their treatment. We will summarize the challenges posed by the growth of next-generation sequencing in the clinical setting, touch briefly on the expansion of the concept of inborn errors of immunity beyond the classic immune system realm, and finally review current developments in targeted therapies, stem cell transplantation, and gene therapy.
Identifiants
pubmed: 32226610
doi: 10.12688/f1000research.21553.1
pmc: PMC7096215
pii:
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Copyright: © 2020 Bucciol G and Meyts I.
Déclaration de conflit d'intérêts
Competing interests: IM is supported by a CSL Behring Chair in Primary Immunodeficiency (paid to institution). GB declares that she has no competing interests.No competing interests were disclosed.No competing interests were disclosed.No competing interests were disclosed.
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