Activation of α7 Nicotinic Acetylcholine Receptor Upregulates HLA-DR and Macrophage Receptors: Potential Role in Adaptive Immunity and in Preventing Immunosuppression.
Adaptive Immunity
/ drug effects
Benzamides
/ pharmacology
Bridged Bicyclo Compounds
/ pharmacology
Cytokines
/ metabolism
HLA-DR Antigens
/ immunology
Humans
Immune Tolerance
/ drug effects
Interleukin-10
/ metabolism
Lipopolysaccharide Receptors
/ metabolism
Lipopolysaccharides
/ metabolism
Macrophages
/ drug effects
Nicotinic Agonists
/ pharmacology
Patch-Clamp Techniques
THP-1 Cells
alpha7 Nicotinic Acetylcholine Receptor
/ genetics
adaptive immunity
immunosuppression
inflammation
innate immunity
macrophages
α7 nAChR
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
27 03 2020
27 03 2020
Historique:
received:
23
02
2020
revised:
16
03
2020
accepted:
23
03
2020
entrez:
2
4
2020
pubmed:
2
4
2020
medline:
16
4
2021
Statut:
epublish
Résumé
Immune response during sepsis is characterized by hyper-inflammation followed by immunosuppression. The crucial role of macrophages is well-known for both septic stages, since they are involved in immune homeostasis and inflammation, their dysfunction being implicated in immunosuppression. The cholinergic anti-inflammatory pathway mediated by macrophage α7 nicotinic acetylcholine receptor (nAChR) represents possible drug target. Although α7 nAChR activation on macrophages reduces the production of proinflammatory cytokines, the role of these receptors in immunological changes at the cellular level is not fully understood. Using α7 nAChR selective agonist PNU 282,987, we investigated the influence of α7 nAChR activation on the expression of cytokines and, for the first time, of the macrophage membrane markers: cluster of differentiation 14 (CD14), human leukocyte antigen-DR (HLA-DR), CD11b, and CD54. Application of PNU 282,987 to THP-1Mϕ (THP-1 derived macrophages) cells led to inward ion currents and Ca
Identifiants
pubmed: 32230846
pii: biom10040507
doi: 10.3390/biom10040507
pmc: PMC7225944
pii:
doi:
Substances chimiques
Benzamides
0
Bridged Bicyclo Compounds
0
CD14 protein, human
0
Cytokines
0
HLA-DR Antigens
0
IL10 protein, human
0
Lipopolysaccharide Receptors
0
Lipopolysaccharides
0
Nicotinic Agonists
0
PNU-282987
0
alpha7 Nicotinic Acetylcholine Receptor
0
Interleukin-10
130068-27-8
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Russian Science Foundation
ID : 16-14-00215p
Pays : International
Organisme : Russian Foundation for Basic Research
ID : 17-00-00063
Pays : International
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