RNA helicase DDX21 mediates nucleotide stress responses in neural crest and melanoma cells.

Animals Cell Line, Tumor DEAD-box RNA Helicases / genetics Dihydroorotate Dehydrogenase Embryo, Nonmammalian Gene Expression Regulation, Developmental Humans Leflunomide / pharmacology Melanocytes / drug effects Neural Crest / drug effects Nucleotides Oxidoreductases Acting on CH-CH Group Donors / genetics Phosphoproteins / genetics Progesterone / metabolism Protein Binding Receptors, Progesterone / genetics Signal Transduction Stress, Physiological / genetics Transcription Elongation, Genetic Transcription Factors / genetics Zebrafish / embryology Zebrafish Proteins / genetics

Journal

Nature cell biology
ISSN: 1476-4679
Titre abrégé: Nat Cell Biol
Pays: England
ID NLM: 100890575

Informations de publication

Date de publication:
04 2020
Historique:
received: 01 04 2019
accepted: 24 02 2020
pubmed: 2 4 2020
medline: 21 4 2020
entrez: 2 4 2020
Statut: ppublish

Résumé

The availability of nucleotides has a direct impact on transcription. The inhibition of dihydroorotate dehydrogenase (DHODH) with leflunomide impacts nucleotide pools by reducing pyrimidine levels. Leflunomide abrogates the effective transcription elongation of genes required for neural crest development and melanoma growth in vivo

Identifiants

DOI: 10.1038/s41556-020-0493-0 PMID: 32231306 PMC: PMC7185069
pubmed: 32231306
doi: 10.1038/s41556-020-0493-0
pii: 10.1038/s41556-020-0493-0
pmc: PMC7185069
mid: NIHMS1566236
doi:

Substances chimiques

Dihydroorotate Dehydrogenase 0
Nucleotides 0
Phosphoproteins 0
Receptors, Progesterone 0
Transcription Factors 0
Zebrafish Proteins 0
Progesterone 4G7DS2Q64Y
Oxidoreductases Acting on CH-CH Group Donors EC 1.3.-
DDX1 protein, human EC 3.6.1.-
DEAD-box RNA Helicases EC 3.6.4.13
ddx21 protein, zebrafish EC 3.6.4.13
Leflunomide G162GK9U4W

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

372-379

Subventions

Organisme : NIGMS NIH HHS
ID : P50 GM107618
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA103846
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA062220
Pays : United States

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Auteurs

Cristina Santoriello (C)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Audrey Sporrij (A)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Song Yang (S)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Ryan A Flynn (RA)

Department of Chemistry, Stanford University, Stanford, CA, USA.
ORCID: 0000-0001-5013-0442

Telmo Henriques (T)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Bilguujin Dorjsuren (B)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Eugenia Custo Greig (E)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Wyatt McCall (W)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Meredith E Stanhope (ME)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Maurizio Fazio (M)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-0083-6601

Michael Superdock (M)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.
ORCID: 0000-0003-4165-4425

Asher Lichtig (A)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Isaac Adatto (I)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.

Brian J Abraham (BJ)

Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
ORCID: 0000-0001-8085-3027

Marian Kalocsay (M)

Laboratory of Systems Pharmacology, Harvard Medical School, Boston, MA, USA.

Michael Jurynec (M)

Department of Orthopedics, University of Utah, Salt Lake City, UT, USA.

Yi Zhou (Y)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA.

Karen Adelman (K)

Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.

Eliezer Calo (E)

Department of Biology and Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, USA.

Leonard I Zon (LI)

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. leonard.zon@enders.tch.harvard.edu.
Stem Cell Program and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Stem Cell Institute, Howard Hughes Medical Institute and Harvard Medical School, Boston, MA, USA. leonard.zon@enders.tch.harvard.edu.
ORCID: 0000-0003-0860-926X

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › RNA nucleotidyltransferases › RNA helicases › DEAD-box RNA helicases › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › Dihydroorotate dehydrogenase › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Structures de l'embryon › Embryon non mammalien › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Régulation de l'expression des gènes au cours du développement › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Isoxazoles › Léflunomide › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Cellules › Cellules épithéliales › Mélanocytes › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Structures de l'embryon › Crête neurale › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Nucléotides › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Oxidoreductases › Oxidoreductases acting on CH-CH group donors › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Phosphoprotéines › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Hormones gonadiques › Hormones sexuelles stéroïdiennes › Congénères de la progestérone › Progestérone › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Métabolisme › Liaison aux protéines › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Récepteurs cytoplasmiques et nucléaires › Récepteurs à la progestérone › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Phénomènes physiologiques › Stress physiologique › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Phénomènes génétiques › Expression des gènes › Transcription génétique › Élongation de la transcription › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Poissons › Cypriniformes › Cyprinidae › Danio zébré › RNA helicase DDX21 mediates nucleotide stress...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines de poisson › Protéines de poisson-zèbre › RNA helicase DDX21 mediates nucleotide stress...