Bacteria-Induced Group 2 Innate Lymphoid Cells in the Stomach Provide Immune Protection through Induction of IgA.
Animals
Cell Lineage
/ genetics
Female
Gastrointestinal Microbiome
/ immunology
Gene Expression Regulation
Helicobacter Infections
/ immunology
Helicobacter pylori
/ growth & development
Immunity, Humoral
Immunity, Innate
Immunoglobulin A
/ biosynthesis
Interleukin-33
/ genetics
Interleukin-5
/ genetics
Interleukin-7
/ genetics
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Primary Cell Culture
Signal Transduction
Stomach
/ immunology
Symbiosis
/ immunology
T-Lymphocyte Subsets
/ classification
Helicobacter pylori
ILC2s
IgA
commensal microbiota
stomach immunity
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
19
08
2019
revised:
15
01
2020
accepted:
06
03
2020
pubmed:
3
4
2020
medline:
5
11
2020
entrez:
3
4
2020
Statut:
ppublish
Résumé
The intestinal microbiota shapes and directs immune development locally and systemically, but little is known about whether commensal microbes in the stomach can impact their immunological microenvironment. Here, we report that group 2 innate lymphoid cells (ILC2s) were the predominant ILC subset in the stomach and show that their homeostasis and effector functions were regulated by local commensal communities. Microbes elicited interleukin-7 (IL-7) and IL-33 production in the stomach, which in turn triggered the propagation and activation of ILC2. Stomach ILC2s were also rapidly induced following infection with Helicobacter pylori. ILC2-derived IL-5 resulted in the production of IgA, which coated stomach bacteria in both specific pathogen-free (SPF) and H. pylori-infected mice. Our study thus identifies ILC2-dependent IgA response that is regulated by the commensal microbiota, which is implicated in stomach protection by eliminating IgA-coated bacteria including pathogenic H. pylori.
Identifiants
pubmed: 32240600
pii: S1074-7613(20)30090-X
doi: 10.1016/j.immuni.2020.03.002
pii:
doi:
Substances chimiques
Il33 protein, mouse
0
Immunoglobulin A
0
Interleukin-33
0
Interleukin-5
0
Interleukin-7
0
interleukin-7, mouse
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
635-649.e4Commentaires et corrections
Type : CommentIn
Type : CommentIn
Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.