Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases.

Autoimmune Diseases / immunology Humans Immunosuppressive Agents / therapeutic use Immunotherapy / methods

Journal

Cell
ISSN: 1097-4172
Titre abrégé: Cell
Pays: United States
ID NLM: 0413066

Informations de publication

Date de publication:
02 04 2020
Historique:
received: 16 12 2019
revised: 17 02 2020
accepted: 05 03 2020
entrez: 4 4 2020
pubmed: 4 4 2020
medline: 21 10 2020
Statut: ppublish

Résumé

Autoimmune diseases are a result of the immune system being misdirected toward its host and have major and increasing unmet clinical needs. In general, present therapies are broadly acting and non-disease specific; consequently, they are associated with numerous side effects. Precise and early intervention strategies are urgently needed. We highlight the challenges, progress, and prospects in achieving these goals.

Identifiants

DOI: 10.1016/j.cell.2020.03.007 PMID: 32243797
pubmed: 32243797
pii: S0092-8674(20)30269-5
doi: 10.1016/j.cell.2020.03.007
pii:
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

63-80

Subventions

Organisme : Medical Research Council
ID : MC_UU_00008/3
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 100308/Z/12/Z
Pays : United Kingdom

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Interests J.R. has received funds to work on autoimmune diseases from Janssen Research & Development, LLC.

Auteurs

Lars Fugger (L)

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark. Electronic address: lars.fugger@imm.ox.ac.uk.

Lise Torp Jensen (LT)

Oxford Centre for Neuroinflammation, Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DS, UK; Department of Clinical Medicine, Aarhus University Hospital, 8200 N Aarhus, Denmark.

Jamie Rossjohn (J)

Infection and Immunity Program and Department of Biochemistry and Molecular Biology, Biomedicine Discovery Institute, Monash University, Clayton, VIC 3800, Australia; Australian Research Council Centre of Excellence in Advanced Molecular Imaging, Monash University, Clayton, VIC 3800, Australia; Institute of Infection and Immunity, Cardiff University, School of Medicine, Heath Park, Cardiff CF14 4XN, UK. Electronic address: jamie.rossjohn@monash.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Challenges, Progress, and Prospects of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Challenges, Progress, and Prospects of...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Challenges, Progress, and Prospects of...
questionsmedicales.fr › Thérapeutique › Biothérapie › Immunothérapie › Challenges, Progress, and Prospects of...