Developmental Regulation of Basket Interneuron Synapses and Behavior through NCAM in Mouse Prefrontal Cortex.
ephrin
perisomatic
sociability
synaptic pruning
working memory
Journal
Cerebral cortex (New York, N.Y. : 1991)
ISSN: 1460-2199
Titre abrégé: Cereb Cortex
Pays: United States
ID NLM: 9110718
Informations de publication
Date de publication:
30 06 2020
30 06 2020
Historique:
received:
15
11
2019
revised:
07
02
2019
pubmed:
7
4
2020
medline:
30
11
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
Parvalbumin (PV)-expressing basket interneurons in the prefrontal cortex (PFC) regulate pyramidal cell firing, synchrony, and network oscillations. Yet, it is unclear how their perisomatic inputs to pyramidal neurons are integrated into neural circuitry and adjusted postnatally. Neural cell adhesion molecule NCAM is expressed in a variety of cells in the PFC and cooperates with EphrinA/EphAs to regulate inhibitory synapse density. Here, analysis of a novel parvalbumin (PV)-Cre: NCAM F/F mouse mutant revealed that NCAM functions presynaptically in PV+ basket interneurons to regulate postnatal elimination of perisomatic synapses. Mutant mice exhibited an increased density of PV+ perisomatic puncta in PFC layer 2/3, while live imaging in mutant brain slices revealed fewer puncta that were dynamically eliminated. Furthermore, EphrinA5-induced growth cone collapse in PV+ interneurons in culture depended on NCAM expression. Electrophysiological recording from layer 2/3 pyramidal cells in mutant PFC slices showed a slower rise time of inhibitory synaptic currents. PV-Cre: NCAM F/F mice exhibited impairments in working memory and social behavior that may be impacted by altered PFC circuitry. These findings suggest that the density of perisomatic synapses of PV+ basket interneurons is regulated postnatally by NCAM, likely through EphrinA-dependent elimination, which is important for appropriate PFC network function and behavior.
Identifiants
pubmed: 32249896
pii: 5816280
doi: 10.1093/cercor/bhaa074
pmc: PMC7325800
doi:
Substances chimiques
Neural Cell Adhesion Molecules
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
4689-4707Subventions
Organisme : NIDCD NIH HHS
ID : R01 DC004551
Pays : United States
Organisme : NICHD NIH HHS
ID : P50 HD103573
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD079124
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH101605
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC009809
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH113280
Pays : United States
Organisme : NIMH NIH HHS
ID : F32 MH111189
Pays : United States
Informations de copyright
© The Author(s) 2020. Published by Oxford University Press. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
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