Lonicera caerulea L. Polyphenols Alleviate Oxidative Stress-Induced Intestinal Environment Imbalance and Lipopolysaccharide-Induced Liver Injury in HFD-Fed Rats by Regulating the Nrf2/HO-1/NQO1 and MAPK Pathways.
Animals
Body Weight
/ drug effects
Colon
/ drug effects
Diet, High-Fat
/ adverse effects
Gastrointestinal Microbiome
/ drug effects
Gene Expression Regulation
/ drug effects
Heme Oxygenase (Decyclizing)
/ metabolism
Lipopolysaccharides
/ toxicity
Liver
/ drug effects
Lonicera
/ chemistry
MAP Kinase Signaling System
/ drug effects
Male
NAD(P)H Dehydrogenase (Quinone)
/ metabolism
NF-E2-Related Factor 2
/ metabolism
Oxidative Stress
/ drug effects
Polyphenols
/ pharmacology
Rats, Sprague-Dawley
intestinal environment
lipopolysaccharide translocation
liver injury
oxidative stress
polyphenols
Journal
Molecular nutrition & food research
ISSN: 1613-4133
Titre abrégé: Mol Nutr Food Res
Pays: Germany
ID NLM: 101231818
Informations de publication
Date de publication:
05 2020
05 2020
Historique:
received:
26
12
2019
revised:
06
03
2020
pubmed:
7
4
2020
medline:
16
7
2021
entrez:
7
4
2020
Statut:
ppublish
Résumé
This study investigates the modulatory effects of Lonicera caerulea L. polyphenols (LCPs) on the intestinal environment and lipopolysaccharide (LPS)-induced liver injury via the nuclear factor erythroid-2-related factor 2/heme oxygenase-1 (HO-1)/NQO1 and mitogen-activated protein kinase (MAPK) pathways in a rat model of oxidative stress damage (OSD). To examine the prebiotic properties of LCP, a model of high-fat-diet-induced OSD is established using Sprague Dawley rats. In the colon, treatment with LCP for 8 weeks ameliorates enhanced intestinal permeability (glucagon-like peptide-2 content and occludin protein increase, whereas claudin-2 protein decreases), intestinal inflammation (levels of pro-inflammatory cytokines, such as tumor necrosis factor-α, interleukin-6, cyclooxygenase-2, and nuclear factor kappa-B p65 (NF-κB p65), decrease), and intestinal OSD (through regulation of the Nrf2/HO-1/NQO1 pathway). Moreover, LCP alleviates LPS-induced liver injury by suppressing the nuclear translocation of NF-κB p65 and activation of the MAPK signaling pathway. Additionally, Bacilli, Lactobacillales, Lactobacillaceae, Lactobacillus, Akkermansia, Actinobacteria, Proteobacteria, Rothia, and Blautia are found to be the key intestinal microbial taxa related to intestinal OSD and LPS-induced liver injury in rats. LCP treatment potentially modulates the intestinal environment and alleviates liver injury by suppressing oxidative-stress-related pathways and altering the composition of the intestinal microbiota.
Identifiants
pubmed: 32250024
doi: 10.1002/mnfr.201901315
doi:
Substances chimiques
Lipopolysaccharides
0
NF-E2-Related Factor 2
0
Nfe2l2 protein, rat
0
Polyphenols
0
Heme Oxygenase (Decyclizing)
EC 1.14.14.18
Hmox1 protein, rat
EC 1.14.14.18
NAD(P)H Dehydrogenase (Quinone)
EC 1.6.5.2
NQO1 protein, rat
EC 1.6.5.2
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e1901315Informations de copyright
© 2020 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
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