Evolution of new enzymes by gene duplication and divergence.
Innovation-amplification-divergence model
directed evolution
enzyme evolution
gene duplication
promiscuity
Journal
The FEBS journal
ISSN: 1742-4658
Titre abrégé: FEBS J
Pays: England
ID NLM: 101229646
Informations de publication
Date de publication:
04 2020
04 2020
Historique:
received:
08
02
2020
revised:
13
03
2020
accepted:
17
03
2020
entrez:
7
4
2020
pubmed:
7
4
2020
medline:
20
1
2021
Statut:
ppublish
Résumé
Thousands of new metabolic and regulatory enzymes have evolved by gene duplication and divergence since the dawn of life. New enzyme activities often originate from promiscuous secondary activities that have become important for fitness due to a change in the environment or a mutation. Mutations that make a promiscuous activity physiologically relevant can occur in the gene encoding the promiscuous enzyme itself, but can also occur elsewhere, resulting in increased expression of the enzyme or decreased competition between the native and novel substrates for the active site. If a newly useful activity is inefficient, gene duplication/amplification will set the stage for divergence of a new enzyme. Even a few mutations can increase the efficiency of a new activity by orders of magnitude. As efficiency increases, amplified gene arrays will shrink to provide two alleles, one encoding the original enzyme and one encoding the new enzyme. Ultimately, genomic rearrangements eliminate co-amplified genes and move newly evolved paralogs to a distant region of the genome.
Identifiants
pubmed: 32250558
doi: 10.1111/febs.15299
pmc: PMC9306413
mid: NIHMS1822963
doi:
Substances chimiques
Oxidoreductases
EC 1.-
Hydrolases
EC 3.-
Aminohydrolases
EC 3.5.4.-
melamine deaminase
EC 3.5.4.-
atrazine chlorohydrolase
EC 3.8.1.8
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, Non-P.H.S.
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
1262-1283Subventions
Organisme : NIGMS NIH HHS
ID : R01 GM134044
Pays : United States
Organisme : NIGMS NIH HHS
ID : 5R01GM134044
Pays : United States
Informations de copyright
© 2020 Federation of European Biochemical Societies.
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