Adenosine A

Aminopyridines / pharmacology Animals Cell Differentiation / drug effects Cells, Cultured Humans Lysophospholipids / pharmacology Oligodendrocyte Precursor Cells / cytology Organophosphates / pharmacology Phosphorylation / drug effects Phosphotransferases (Alcohol Group Acceptor) / metabolism Potassium Channels / metabolism Purines / pharmacology RNA Interference Rats, Wistar Receptor, Adenosine A2B / genetics Signal Transduction / drug effects Sphingosine / analogs & derivatives Sphingosine-1-Phosphate Receptors / metabolism
A(2B) adenosine receptors K(+) currents OPC differentiation Remyelination Sphingosine-1-phosphate

Journal

Biochemical pharmacology
ISSN: 1873-2968
Titre abrégé: Biochem Pharmacol
Pays: England
ID NLM: 0101032

Informations de publication

Date de publication:
07 2020
Historique:
received: 10 02 2020
accepted: 01 04 2020
pubmed: 7 4 2020
medline: 29 12 2020
entrez: 7 4 2020
Statut: ppublish

Résumé

Oligodendrocytes are the only myelinating cells in the brain and differentiate from their progenitors (OPCs) throughout adult life. However, this process fails in demyelinating pathologies. Adenosine is emerging as an important player in OPC differentiation and we recently demonstrated that adenosine A

Identifiants

DOI: 10.1016/j.bcp.2020.113956 PMID: 32251679
pubmed: 32251679
pii: S0006-2952(20)30184-2
doi: 10.1016/j.bcp.2020.113956
pii:
doi:

Substances chimiques

Aminopyridines 0
BAY 60-6583 0
FTY 720P 0
Lysophospholipids 0
N-(4-acetylphenyl)-2-(4-(2,3,6,7-tetrahydro-2,6-dioxo-1,3-dipropyl-1H-purin-8-yl)phenoxy)acetamide 0
Organophosphates 0
Potassium Channels 0
Purines 0
Receptor, Adenosine A2B 0
Sphingosine-1-Phosphate Receptors 0
sphingosine 1-phosphate 26993-30-6
Phosphotransferases (Alcohol Group Acceptor) EC 2.7.1.-
sphingosine kinase EC 2.7.1.-
Sphingosine NGZ37HRE42

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

113956

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Auteurs

Elisabetta Coppi (E)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy. Electronic address: elisabetta.coppi@unifi.it.

Federica Cherchi (F)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

Irene Fusco (I)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

Ilaria Dettori (I)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

Lisa Gaviano (L)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

Giada Magni (G)

Istituto di Fisica Applicata, CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Florence, Italy.

Daniela Catarzi (D)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Italy.

Vittoria Colotta (V)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Italy.

Flavia Varano (F)

Department of NEUROFARBA, Section of Pharmaceutical and Nutraceutical Sciences, University of Florence, Italy.

Francesca Rossi (F)

Istituto di Fisica Applicata, CNR, Via Madonna del Piano 10, Sesto Fiorentino 50019, Florence, Italy.

Caterina Bernacchioni (C)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy.

Chiara Donati (C)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy.

Paola Bruni (P)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy.

Felicita Pedata (F)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

Francesca Cencetti (F)

Department of Experimental and Clinical Biomedical Sciences, University of Florence, Italy.

Anna Maria Pugliese (AM)

Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), Section of Pharmacology and Toxicology, University of Florence, Italy.

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Classifications MeSH

questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Aminopyridines › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Adenosine A
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Adenosine A
questionsmedicales.fr › Cellules › Cellules cultivées › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Adenosine A
questionsmedicales.fr › Lipides › Lipides membranaires › Phospholipides › Glycérophosphate › Acides phosphatidiques › Lysophospholipides › Adenosine A
questionsmedicales.fr › Cellules › Cellules souches › Cellules souches neurales › Précurseurs des oligodendrocytes › Adenosine A
questionsmedicales.fr › Composés chimiques organiques › Composés organiques du phosphore › Organophosphates › Adenosine A
questionsmedicales.fr › Métabolisme › Phosphorylation › Adenosine A
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Phosphotransferases (Alcohol Group Acceptor) › Adenosine A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Canaux ioniques › Canaux potassiques › Adenosine A
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Purines › Adenosine A
questionsmedicales.fr › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Extinction de l'expression des gènes › Interférence par ARN › Adenosine A
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Rat Wistar › Adenosine A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs purinergiques › Récepteurs purinergiques P1 › Récepteurs A2 à l'adénosine › Récepteur A2B à l'adénosine › Adenosine A
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Adenosine A
questionsmedicales.fr › Composés chimiques organiques › Amines › Aminoalcools › Sphingosine › Adenosine A
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs couplés aux protéines G › Récepteurs aux lysophospholipides › Récepteurs aux lysosphingolipides › Récepteurs de la sphingosine-1-phosphate › Adenosine A