An orally bioavailable broad-spectrum antiviral inhibits SARS-CoV-2 in human airway epithelial cell cultures and multiple coronaviruses in mice.
Adenosine Monophosphate
/ administration & dosage
Alanine
/ administration & dosage
Animals
Antibiotic Prophylaxis
Antiviral Agents
/ administration & dosage
Betacoronavirus
/ physiology
COVID-19
Cell Line
Coronavirus Infections
/ drug therapy
Cytidine
/ administration & dosage
Disease Models, Animal
Drug Resistance, Viral
Humans
Hydroxylamines
Lung
/ pathology
Mice
Mice, Inbred C57BL
Middle East Respiratory Syndrome Coronavirus
/ physiology
Models, Molecular
Mutation
/ drug effects
Pandemics
Pneumonia, Viral
/ drug therapy
Primary Cell Culture
RNA, Viral
RNA-Dependent RNA Polymerase
/ chemistry
Random Allocation
Respiratory System
/ cytology
Ribonucleosides
/ administration & dosage
SARS-CoV-2
Virus Replication
/ drug effects
Journal
Science translational medicine
ISSN: 1946-6242
Titre abrégé: Sci Transl Med
Pays: United States
ID NLM: 101505086
Informations de publication
Date de publication:
29 04 2020
29 04 2020
Historique:
received:
05
03
2020
accepted:
03
04
2020
pubmed:
8
4
2020
medline:
6
5
2020
entrez:
8
4
2020
Statut:
ppublish
Résumé
Coronaviruses (CoVs) traffic frequently between species resulting in novel disease outbreaks, most recently exemplified by the newly emerged SARS-CoV-2, the causative agent of COVID-19. Here, we show that the ribonucleoside analog β-d-N
Identifiants
pubmed: 32253226
pii: scitranslmed.abb5883
doi: 10.1126/scitranslmed.abb5883
pmc: PMC7164393
pii:
doi:
Substances chimiques
Antiviral Agents
0
Hydroxylamines
0
RNA, Viral
0
Ribonucleosides
0
remdesivir
3QKI37EEHE
Adenosine Monophosphate
415SHH325A
Cytidine
5CSZ8459RP
N(4)-hydroxycytidine
C3D11PV2O4
RNA-Dependent RNA Polymerase
EC 2.7.7.48
Alanine
OF5P57N2ZX
molnupiravir
YA84KI1VEW
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : NIAID NIH HHS
ID : HHSN272201500008C
Pays : United States
Organisme : NIAID NIH HHS
ID : F31 AI133952
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI108197
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI112541
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI142759
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI132178
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK065988
Pays : United States
Organisme : NIAID NIH HHS
ID : U19 AI109680
Pays : United States
Informations de copyright
Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution License 4.0 (CC BY).
Références
Antimicrob Agents Chemother. 2018 Jul 27;62(8):
pubmed: 29891600
Sci Rep. 2017 Mar 06;7:43395
pubmed: 28262699
Nucleic Acids Res. 2006;34(22):6438-49
pubmed: 17130163
Nature. 2020 May;581(7809):465-469
pubmed: 32235945
PLoS One. 2015 Jun 26;10(6):e0131451
pubmed: 26115403
Nat Microbiol. 2016 Nov 28;2:16226
pubmed: 27892925
Antimicrob Agents Chemother. 2017 Mar 24;61(4):
pubmed: 28137799
J Crit Care. 2020 Jun;57:279-283
pubmed: 32173110
Methods Mol Med. 2005;107:183-206
pubmed: 15492373
Virology. 2004 Dec 5;330(1):8-15
pubmed: 15527829
J Virol. 2005 Dec;79(24):15511-24
pubmed: 16306622
Proc Natl Acad Sci U S A. 2013 Oct 8;110(41):16598-603
pubmed: 24062443
Nucleic Acids Res. 2016 Jul 8;44(W1):W344-50
pubmed: 27166375
Virology. 2018 Apr;517:98-107
pubmed: 29277291
N Engl J Med. 2020 May 7;382(19):1787-1799
pubmed: 32187464
Clin Infect Dis. 2011 Feb 15;52(4):457-65
pubmed: 21220768
Am J Respir Cell Mol Biol. 2011 May;44(5):725-38
pubmed: 21531958
J Virol. 2019 Nov 26;93(24):
pubmed: 31578288
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20166-71
pubmed: 22135472
mBio. 2013 Sep 10;4(5):e00650-13
pubmed: 24023385
JAMA. 2020 Mar 17;323(11):1061-1069
pubmed: 32031570
J Virol. 2018 Jan 17;92(3):
pubmed: 29167335
J Virol. 2002 Nov;76(21):11065-78
pubmed: 12368349
Sci Transl Med. 2017 Jun 28;9(396):
pubmed: 28659436
Virology. 2006 Jul 20;351(1):180-7
pubmed: 16647731
J Virol. 2012 Dec;86(23):12816-25
pubmed: 22993147
Methods Mol Biol. 2013;945:109-21
pubmed: 23097104
Lancet. 2003 May 24;361(9371):1767-72
pubmed: 12781535
Nature. 2018 Apr;556(7700):255-258
pubmed: 29618817
Nat Rev Drug Discov. 2016 May;15(5):327-47
pubmed: 26868298
Antiviral Res. 2019 Sep;169:104541
pubmed: 31233808
N Engl J Med. 2012 Nov 8;367(19):1814-20
pubmed: 23075143
Proc Natl Acad Sci U S A. 2008 Dec 16;105(50):19944-9
pubmed: 19036930
mBio. 2017 Apr 4;8(2):
pubmed: 28377531
Viruses. 2019 Apr 04;11(4):
pubmed: 30987343
Nat Commun. 2019 May 28;10(1):2342
pubmed: 31138817
J Virol. 2020 Mar 17;94(7):
pubmed: 31996437
PLoS One. 2011;6(6):e21207
pubmed: 21701593
mBio. 2018 Mar 6;9(2):
pubmed: 29511076
JAMA. 2020 Feb 25;323(8):707-708
pubmed: 31971553
mBio. 2014 Mar 25;5(2):e00047-14
pubmed: 24667706
Viruses. 2015 Dec 01;7(12):6233-40
pubmed: 26633464
Proc Natl Acad Sci U S A. 2016 Mar 15;113(11):3048-53
pubmed: 26976607
PLoS Pathog. 2018 Feb 9;14(2):e1006889
pubmed: 29425244
Emerg Infect Dis. 2020 Jun;26(6):1266-1273
pubmed: 32160149
Proc Natl Acad Sci U S A. 2013 Oct 1;110(40):16157-62
pubmed: 24043791
J Virol. 2015 Aug;89(16):8540-55
pubmed: 26041299
J Virol. 2011 Jan;85(1):217-30
pubmed: 20980507
Nature. 2016 Mar 17;531(7594):381-5
pubmed: 26934220
Sci Transl Med. 2019 Oct 23;11(515):
pubmed: 31645453
Nat Commun. 2020 Jan 10;11(1):222
pubmed: 31924756
Science. 2020 May 29;368(6494):1012-1015
pubmed: 32303590
PLoS Pathog. 2007 Jan;3(1):e5
pubmed: 17222058
Nat Rev Microbiol. 2016 Aug;14(8):523-34
pubmed: 27344959
PLoS Pathog. 2013 Aug;9(8):e1003565
pubmed: 23966862
Sci Transl Med. 2014 Sep 10;6(253):253ps10
pubmed: 25210060
Virol J. 2015 Dec 22;12:221
pubmed: 26689940
Lancet Infect Dis. 2020 Jun;20(6):697-706
pubmed: 32224310
Nat Med. 2015 Dec;21(12):1508-13
pubmed: 26552008
N Engl J Med. 2016 Sep 29;375(13):1303-5
pubmed: 27682053
Emerg Infect Dis. 2003 Jun;9(6):713-7
pubmed: 12781012
PLoS Pathog. 2018 Jan 2;14(1):e1006810
pubmed: 29293660