Conformational enhancement of fidelity in toehold-sequestered DNA nanodevices.
Journal
Chemical communications (Cambridge, England)
ISSN: 1364-548X
Titre abrégé: Chem Commun (Camb)
Pays: England
ID NLM: 9610838
Informations de publication
Date de publication:
11 May 2020
11 May 2020
Historique:
pubmed:
8
4
2020
medline:
30
12
2020
entrez:
8
4
2020
Statut:
ppublish
Résumé
The operation of DNA nanodevices is often limited by erroneous strand displacement. Here we demonstrate simple design principles that reduce such leakage by up to two orders of magnitude. Enhanced operational robustness against multiple spurious inputs was obtained by simply relocating toehold overhangs to external locations and strengthening adjacent G-C clamping.
Substances chimiques
DNA
9007-49-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM