Quartz Dust Exposure Affects NLRP3 Inflammasome Activation and Plasma Levels of IL-18 and IL-1Ra in Iron Foundry Workers.
Adult
CARD Signaling Adaptor Proteins
/ blood
Caspase 1
/ blood
Female
Humans
Inflammasomes
/ blood
Interleukin 1 Receptor Antagonist Protein
/ blood
Interleukin-18
/ blood
Interleukin-1beta
/ blood
Male
Middle Aged
NLR Family, Pyrin Domain-Containing 3 Protein
/ blood
Neoplasm Proteins
/ blood
Polymorphism, Single Nucleotide
/ genetics
Journal
Mediators of inflammation
ISSN: 1466-1861
Titre abrégé: Mediators Inflamm
Pays: United States
ID NLM: 9209001
Informations de publication
Date de publication:
2020
2020
Historique:
received:
23
09
2019
accepted:
21
12
2019
entrez:
8
4
2020
pubmed:
8
4
2020
medline:
2
2
2021
Statut:
epublish
Résumé
To study the association between inhalation of particulate matter or quartz in Swedish iron foundries and the effects on NLRP3 inflammasome activation. Particle exposure measurements were performed during an eight-hour work day for 85 foundry workers at three Swedish iron foundries. Personal sampling was used for measurement of respirable quartz and dust and stationary measurements to obtain exposure measurements for inhalable dust and PM The average exposure levels of respirable dust and quartz were 0.85 and 0.052 mg/m The results indicate that exposure levels of PM in the iron foundry environment can affect the NLRP3 inflammasome and systemic inflammation.
Identifiants
pubmed: 32256196
doi: 10.1155/2020/8490908
pmc: PMC7091550
doi:
Substances chimiques
CARD Signaling Adaptor Proteins
0
CARD8 protein, human
0
Inflammasomes
0
Interleukin 1 Receptor Antagonist Protein
0
Interleukin-18
0
Interleukin-1beta
0
NLR Family, Pyrin Domain-Containing 3 Protein
0
NLRP3 protein, human
0
Neoplasm Proteins
0
Caspase 1
EC 3.4.22.36
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
8490908Informations de copyright
Copyright © 2020 Alexander Hedbrant et al.
Déclaration de conflit d'intérêts
The authors declare no conflicts of interest.
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