Development and validation of an ambulatory piglet model for short bowel syndrome with ileo-colonic anastomosis.
Short bowel syndrome
animal model
bowel resection
ileocecal valve resection
intestinal failure
intestinal failure-associated liver disease
piglet model
Journal
Experimental biology and medicine (Maywood, N.J.)
ISSN: 1535-3699
Titre abrégé: Exp Biol Med (Maywood)
Pays: England
ID NLM: 100973463
Informations de publication
Date de publication:
06 2020
06 2020
Historique:
pubmed:
9
4
2020
medline:
20
2
2021
entrez:
9
4
2020
Statut:
ppublish
Résumé
Short bowel syndrome is associated with significant comorbidities and mortality. This study is important as unlike current systems, it provides a validated piglet model which mirrors anatomical, histological, and serological characteristics observed in human SBS. This model can be used to advance knowledge into mechanistic pathways and therapeutic modalities to improve outcomes for SBS patients. This study is novel in that in addition to significant reduction in the remnant bowel and noted liver disease, we also developed a method to emulate ileocecal valve resection and described gut adaptive responses which has important clinical implications in humans.
Identifiants
pubmed: 32264693
doi: 10.1177/1535370220915881
pmc: PMC7357144
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1049-1057Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK098623
Pays : United States
Organisme : NIDDK NIH HHS
ID : R03 DK121046
Pays : United States
Organisme : NIBIB NIH HHS
ID : R03 EB015955
Pays : United States
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