Estrogen Reverses HDAC Inhibitor-Mediated Repression of
3' Untranslated Regions
Animals
Autoantibodies
/ biosynthesis
B-Lymphocytes
/ drug effects
Base Sequence
Binding, Competitive
Butyrates
/ pharmacology
Cytidine Deaminase
/ biosynthesis
Down-Regulation
/ drug effects
Estradiol
/ pharmacology
Estrogen Receptor alpha
/ deficiency
Female
Gene Expression Regulation
/ drug effects
Histone Deacetylase Inhibitors
/ pharmacology
Humans
Immunoglobulin Class Switching
/ drug effects
Isoantibodies
/ biosynthesis
Lupus Erythematosus, Systemic
/ drug therapy
Mice
Mice, Inbred MRL lpr
Mice, Knockout
MicroRNAs
/ antagonists & inhibitors
Phosphoprotein Phosphatases
/ genetics
Phosphoric Monoester Hydrolases
/ genetics
Promoter Regions, Genetic
Proof of Concept Study
Propionates
/ pharmacology
Recombinant Proteins
/ metabolism
Sequence Alignment
Sex Characteristics
Transduction, Genetic
Valproic Acid
/ pharmacology
AID
Aicda
HDAC inhibitor
antibody response
class switch DNA recombination
estrogen
estrogen receptor α
microRNA
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2020
2020
Historique:
received:
24
01
2020
accepted:
03
03
2020
entrez:
9
4
2020
pubmed:
9
4
2020
medline:
9
3
2021
Statut:
epublish
Résumé
Estrogen contributes to females' strong antibody response to microbial vaccines and proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in females. We have hypothesized that this is due to estrogen-mediated potentiation of class switch DNA recombination (CSR) and somatic hypermutation (SHM). As we have shown, estrogen boosts AID expression, which is critical for both CSR and SHM, through upregulation of HoxC4, which together with NF-κB critically mediates
Identifiants
pubmed: 32265934
doi: 10.3389/fimmu.2020.00491
pmc: PMC7105609
doi:
Substances chimiques
3' Untranslated Regions
0
Autoantibodies
0
Butyrates
0
Esr1 protein, mouse
0
Estrogen Receptor alpha
0
Histone Deacetylase Inhibitors
0
Isoantibodies
0
MIRN26A microRNA, human
0
MicroRNAs
0
Mirn26 microRNA, mouse
0
Propionates
0
Recombinant Proteins
0
Estradiol
4TI98Z838E
Valproic Acid
614OI1Z5WI
Phosphoprotein Phosphatases
EC 3.1.3.16
Phosphoric Monoester Hydrolases
EC 3.1.3.2
AICDA (activation-induced cytidine deaminase)
EC 3.5.4.-
Cytidine Deaminase
EC 3.5.4.5
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
491Subventions
Organisme : NIAID NIH HHS
ID : R01 AI079705
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105813
Pays : United States
Organisme : NIAID NIH HHS
ID : T32 AI138944
Pays : United States
Informations de copyright
Copyright © 2020 Casali, Shen, Xu, Qiu, Chupp, Im, Xu and Zan.
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