GFAP IgG associated inflammatory polyneuropathy.
Antibodies
GFAP
Peripheral neuropathy
Polyradiculoneuropathy
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 06 2020
15 06 2020
Historique:
received:
25
02
2020
revised:
22
03
2020
accepted:
31
03
2020
pubmed:
10
4
2020
medline:
11
11
2020
entrez:
10
4
2020
Statut:
ppublish
Résumé
GFAP (glial fibrillary acidic protein)-IgG is predominantly associated with meningoencephalomyelitis, and neuropathy presentations are rare. We reviewed clinical, electrodiagnostic and histopathological presentations of GFAP-IgG associated peripheral neuropathy. We identified six cases, five of whom had peripheral neuropathy as the initial presentation. Acute/subacute polyradicluoneuropathy or proximal nerve involvement was a common presentation. Three had demyelinating neuropathies on electrophysiological studies. Nerve biopsies (n = 2) demonstrated T-cell predominant perivascular inflammatory collections, and all patients with clinical follow up responded favorably to immunotherapy. GFAP neuropathy represents a potentially treatable immune-mediated neuropathy and can occur with or without co-existing meningoencephalomyelitis.
Sections du résumé
BACKGROUND
GFAP (glial fibrillary acidic protein)-IgG is predominantly associated with meningoencephalomyelitis, and neuropathy presentations are rare.
METHODS
We reviewed clinical, electrodiagnostic and histopathological presentations of GFAP-IgG associated peripheral neuropathy.
RESULTS
We identified six cases, five of whom had peripheral neuropathy as the initial presentation. Acute/subacute polyradicluoneuropathy or proximal nerve involvement was a common presentation. Three had demyelinating neuropathies on electrophysiological studies. Nerve biopsies (n = 2) demonstrated T-cell predominant perivascular inflammatory collections, and all patients with clinical follow up responded favorably to immunotherapy.
CONCLUSION
GFAP neuropathy represents a potentially treatable immune-mediated neuropathy and can occur with or without co-existing meningoencephalomyelitis.
Identifiants
pubmed: 32272393
pii: S0165-5728(20)30107-7
doi: 10.1016/j.jneuroim.2020.577233
pii:
doi:
Substances chimiques
Autoantibodies
0
Autoantigens
0
GFAP protein, human
0
Glial Fibrillary Acidic Protein
0
Immunoglobulin G
0
Immunosuppressive Agents
0
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577233Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.