Formoterol, a β
Animals
Brain Injuries, Traumatic
/ complications
Cognition
/ drug effects
Disease Models, Animal
Formoterol Fumarate
/ pharmacology
Hippocampus
/ drug effects
Male
Maze Learning
/ drug effects
Mice
Mice, Inbred C57BL
Mitochondria
/ drug effects
Neurons
/ drug effects
Organelle Biogenesis
Recovery of Function
/ drug effects
White Matter
/ drug effects
Calcium buffering
Controlled cortical impact
Mitochondrial bioenergetics
Novel object recognition
PGC1-α
Journal
Neurobiology of disease
ISSN: 1095-953X
Titre abrégé: Neurobiol Dis
Pays: United States
ID NLM: 9500169
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
18
09
2019
revised:
12
03
2020
accepted:
05
04
2020
pubmed:
15
4
2020
medline:
9
7
2021
entrez:
15
4
2020
Statut:
ppublish
Résumé
Traumatic brain injury (TBI) leads to acute necrosis at the site of injury followed by a sequence of secondary events lasting from hours to weeks and often years. Targeting mitochondrial impairment following TBI has shown improvements in brain mitochondrial bioenergetics and neuronal function. Recently formoterol, a highly selective β
Identifiants
pubmed: 32289370
pii: S0969-9961(20)30141-8
doi: 10.1016/j.nbd.2020.104866
pii:
doi:
Substances chimiques
Formoterol Fumarate
W34SHF8J2K
Types de publication
Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
104866Subventions
Organisme : BLRD VA
ID : I01 BX003405
Pays : United States
Informations de copyright
Copyright © 2020 The Authors. Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Competing Interest The authors declare that they have no conflicts of interest with the contents of this article.