Stromal Cells Covering Omental Fat-Associated Lymphoid Clusters Trigger Formation of Neutrophil Aggregates to Capture Peritoneal Contaminants.
Acute Disease
Animals
Appendicitis
/ genetics
Cell Communication
/ immunology
Chemokine CXCL1
/ genetics
Epithelial Cells
/ immunology
Epithelium
/ immunology
Escherichia coli
/ growth & development
Extracellular Traps
/ immunology
Female
Gene Expression
Humans
Lymphocytes
/ immunology
Mice
Mice, Inbred C57BL
Mice, Knockout
Neutrophil Infiltration
Neutrophils
/ immunology
Omentum
/ immunology
Peritonitis
/ chemically induced
Protein-Arginine Deiminase Type 4
/ genetics
Sequence Analysis, RNA
Single-Cell Analysis
Stromal Cells
/ immunology
Tissue Culture Techniques
Zymosan
/ administration & dosage
CXCL1
FALC
NETs
mesothelium
neutrophil
omentum
peritonitis
scRNA-seq
stroma
Journal
Immunity
ISSN: 1097-4180
Titre abrégé: Immunity
Pays: United States
ID NLM: 9432918
Informations de publication
Date de publication:
14 04 2020
14 04 2020
Historique:
received:
26
09
2019
revised:
11
02
2020
accepted:
18
03
2020
entrez:
16
4
2020
pubmed:
16
4
2020
medline:
5
11
2020
Statut:
ppublish
Résumé
The omentum is a visceral adipose tissue rich in fat-associated lymphoid clusters (FALCs) that collects peritoneal contaminants and provides a first layer of immunological defense within the abdomen. Here, we investigated the mechanisms that mediate the capture of peritoneal contaminants during peritonitis. Single-cell RNA sequencing and spatial analysis of omental stromal cells revealed that the surface of FALCs were covered by CXCL1
Identifiants
pubmed: 32294409
pii: S1074-7613(20)30124-2
doi: 10.1016/j.immuni.2020.03.011
pmc: PMC7156918
pii:
doi:
Substances chimiques
Chemokine CXCL1
0
Cxcl1 protein, mouse
0
Zymosan
9010-72-4
Protein-Arginine Deiminase Type 4
EC 3.5.3.15
peptidylarginine deiminase 4, mouse
EC 3.5.3.15
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
700-715.e6Subventions
Organisme : Medical Research Council
ID : MR/S008020/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 213697/Z/18/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/M011542/1
Pays : United Kingdom
Organisme : British Heart Foundation
ID : RE/18/5/34216
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/P008887/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 103749
Pays : United Kingdom
Commentaires et corrections
Type : CommentIn
Informations de copyright
Copyright © 2020 The Author(s). Published by Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of Interests The authors declare no competing interests.
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