Role of inflammasome activation in tumor immunity triggered by immune checkpoint blockers.

Animals Antineoplastic Agents, Immunological / therapeutic use Apyrase / antagonists & inhibitors CD8-Positive T-Lymphocytes / immunology Humans Inflammasomes / immunology Membrane Proteins / antagonists & inhibitors Neoplasm Proteins / antagonists & inhibitors Neoplasms / drug therapy Th17 Cells / immunology
Cancer checkpoint blockade immunotherapy inflammasome

Journal

Clinical and experimental immunology
ISSN: 1365-2249
Titre abrégé: Clin Exp Immunol
Pays: England
ID NLM: 0057202

Informations de publication

Date de publication:
05 2020
Historique:
received: 08 10 2019
revised: 17 03 2020
accepted: 19 03 2020
entrez: 17 4 2020
pubmed: 17 4 2020
medline: 21 10 2020
Statut: ppublish

Résumé

Immune checkpoint blockers improve the overall survival of a limited number of patients among different cancers. Identifying pathways that influence the immunological and clinical response to treatment is critical to improve the therapeutic efficacy and predict clinical responses. Recently, a key role has been assigned to innate immune mechanisms in checkpoint blockade-driven anti-tumor responses. However, inflammatory pathways can both improve and impair anti-tumor immunity. In this review, we discuss how different inflammatory pathways, particularly inflammasome activation, can influence the clinical outcome of immune checkpoint blockers. Inflammasome activation may reinforce anti-tumor immunity by boosting CD8

Identifiants

DOI: 10.1111/cei.13433 PMID: 32297328 PMC: PMC7160664
pubmed: 32297328
doi: 10.1111/cei.13433
pmc: PMC7160664
doi:

Substances chimiques

Antineoplastic Agents, Immunological 0
Inflammasomes 0
Membrane Proteins 0
Neoplasm Proteins 0
TMEM176B protein, human 0
Apyrase EC 3.6.1.5
ENTPD1 protein, human EC 3.6.1.5

Types de publication

Journal Article Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

155-162

Informations de copyright

© 2020 British Society for Immunology.

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Auteurs

M Segovia (M)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Immunobiology Department, Faculty of Medicine, University of the Republic, Montevideo, Uruguay.

S Russo (S)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Immunobiology Department, Faculty of Medicine, University of the Republic, Montevideo, Uruguay.

M R Girotti (MR)

Laboratory of Translational Immuno-Oncology, Institute of Biology and Experimental Medicine (IBYME), National Council of Scientific and Technical Investigations (CONICET), Buenos Aires, Argentina.

G A Rabinovich (GA)

Laboratory of Immunopathology, Institute of Biology and Experimental Medicine (IBYME), National Council of Scientific and Technical Investigations (CONICET), Buenos Aires, Argentina.
School of Exact and Natural Sciences, University of Buenos Aires, Buenos Aires, Argentina.

M Hill (M)

Laboratory of Immunoregulation and Inflammation, Institut Pasteur de Montevideo, Montevideo, Uruguay.
Immunobiology Department, Faculty of Medicine, University of the Republic, Montevideo, Uruguay.
ORCID: 0000-0002-1589-0320

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Animaux › Role of inflammasome activation in tumor...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Antinéoplasiques › Antinéoplasiques immunologiques › Role of inflammasome activation in tumor...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Acid anhydride hydrolases › Apyrase › Role of inflammasome activation in tumor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › Role of inflammasome activation in tumor...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Role of inflammasome activation in tumor...
questionsmedicales.fr › Structures macromoléculaires › Complexes multiprotéiques › Inflammasomes › Role of inflammasome activation in tumor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Role of inflammasome activation in tumor...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines tumorales › Role of inflammasome activation in tumor...
questionsmedicales.fr › Tumeurs › Role of inflammasome activation in tumor...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Role of inflammasome activation in tumor...