Multidrug-resistant cytomegalovirus infection in a patient with granulomatosis with polyangiitis during immunosuppressive treatment.
Antiviral Agents
/ therapeutic use
Cidofovir
/ therapeutic use
Cyclophosphamide
/ adverse effects
Cytomegalovirus
/ drug effects
Cytomegalovirus Infections
/ drug therapy
Drug Resistance, Multiple, Viral
Female
Ganciclovir
/ therapeutic use
Granulomatosis with Polyangiitis
/ drug therapy
Humans
Immunosuppressive Agents
/ adverse effects
Middle Aged
Prednisone
/ adverse effects
Journal
Antiviral therapy
ISSN: 2040-2058
Titre abrégé: Antivir Ther
Pays: England
ID NLM: 9815705
Informations de publication
Date de publication:
2020
2020
Historique:
accepted:
27
02
2020
pubmed:
17
4
2020
medline:
5
10
2021
entrez:
17
4
2020
Statut:
ppublish
Résumé
Cytomegalovirus (CMV) infection is a major complication in immunocompromised patients, including those with autoimmune diseases. Here, we describe the first case of granulomatosis with polyangiitis treated with steroids and cyclophosphamide, complicated by a multidrug-resistant (MDR) CMV infection in presence of weak antiviral cellular immunity. Since reports regarding CMV infection in rheumatological patients are rarely described and no guidelines on its management exist, the described case contributes to identify potential strategies to predict the risk of CMV disease and developing of MDR-CMV in these patients, through virological and immunological surveillance.
Substances chimiques
Antiviral Agents
0
Immunosuppressive Agents
0
Cyclophosphamide
8N3DW7272P
Cidofovir
JIL713Q00N
Ganciclovir
P9G3CKZ4P5
Prednisone
VB0R961HZT
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM