Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities.
Animals
Anti-HIV Agents
/ chemical synthesis
Capsid Proteins
/ antagonists & inhibitors
Cell Line, Tumor
Drug Design
Female
HIV-1
/ chemistry
HIV-2
/ chemistry
Humans
Male
Mice
Microsomes, Liver
/ metabolism
Molecular Structure
Phenylalanine
/ analogs & derivatives
Rats, Sprague-Dawley
Structure-Activity Relationship
Sulfonamides
/ chemical synthesis
Virus Replication
/ drug effects
Journal
Journal of medicinal chemistry
ISSN: 1520-4804
Titre abrégé: J Med Chem
Pays: United States
ID NLM: 9716531
Informations de publication
Date de publication:
14 05 2020
14 05 2020
Historique:
pubmed:
17
4
2020
medline:
3
11
2020
entrez:
17
4
2020
Statut:
ppublish
Résumé
The HIV-1 CA protein has gained remarkable attention as a promising therapeutic target for the development of new antivirals, due to its pivotal roles in HIV-1 replication (structural and regulatory). Herein, we report the design and synthesis of three series of benzenesulfonamide-containing phenylalanine derivatives obtained by further structural modifications of
Identifiants
pubmed: 32298111
doi: 10.1021/acs.jmedchem.0c00015
pmc: PMC8011991
mid: NIHMS1683834
doi:
Substances chimiques
Anti-HIV Agents
0
Capsid Proteins
0
Sulfonamides
0
Phenylalanine
47E5O17Y3R
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
4790-4810Subventions
Organisme : NIAID NIH HHS
ID : R01 AI150491
Pays : United States
Organisme : NIGMS NIH HHS
ID : R01 GM125396
Pays : United States
Organisme : NIMH NIH HHS
ID : T32 MH079785
Pays : United States
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