Whole-genome genotyping and resequencing reveal the association of a deletion in the complex interferon alpha gene cluster with hypothyroidism in dogs.
Animals
Breeding
DNA Copy Number Variations
Dog Diseases
/ genetics
Dogs
Genetic Predisposition to Disease
Genome-Wide Association Study
Genomics
Genotype
Hashimoto Disease
/ genetics
Interferon-alpha
/ genetics
Multigene Family
Polymorphism, Single Nucleotide
Sequence Deletion
Thyroiditis, Autoimmune
/ genetics
Dog
Fine-mapping
Genome-wide association study
Hypothyroidism
Long-read sequencing
Type I interferon genes
Whole-genome sequencing
Journal
BMC genomics
ISSN: 1471-2164
Titre abrégé: BMC Genomics
Pays: England
ID NLM: 100965258
Informations de publication
Date de publication:
16 Apr 2020
16 Apr 2020
Historique:
received:
29
11
2019
accepted:
24
03
2020
entrez:
18
4
2020
pubmed:
18
4
2020
medline:
15
12
2020
Statut:
epublish
Résumé
Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic risk factors potentially involved in the susceptibility to the disease in the high-risk Giant Schnauzer dog breed. By employing genome-wide association followed by fine-mapping (top variant p-value = 5.7 × 10 Our results expand the current knowledge on genetic determinants of canine hypothyroidism by revealing a significant link with the human counterpart disease, potentially translating into better diagnostic tools across species, and may contribute to improved canine breeding strategies.
Sections du résumé
BACKGROUND
BACKGROUND
Hypothyroidism is a common complex endocrinopathy that typically has an autoimmune etiology, and it affects both humans and dogs. Genetic and environmental factors are both known to play important roles in the disease development. In this study, we sought to identify the genetic risk factors potentially involved in the susceptibility to the disease in the high-risk Giant Schnauzer dog breed.
RESULTS
RESULTS
By employing genome-wide association followed by fine-mapping (top variant p-value = 5.7 × 10
CONCLUSIONS
CONCLUSIONS
Our results expand the current knowledge on genetic determinants of canine hypothyroidism by revealing a significant link with the human counterpart disease, potentially translating into better diagnostic tools across species, and may contribute to improved canine breeding strategies.
Identifiants
pubmed: 32299354
doi: 10.1186/s12864-020-6700-3
pii: 10.1186/s12864-020-6700-3
pmc: PMC7160888
doi:
Substances chimiques
Interferon-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
307Subventions
Organisme : European Commission (LUPA)
ID : FP7 201370
Organisme : Svenska Forskningsrådet Formas (SE)
ID : 2010-629
Organisme : Agria Djurförsäkring (SE) and Svenska KennelKlubben (SE)
ID : N2011-0039
Organisme : European Science Foundation
ID : EURYI Award
Organisme : European Research Council
ID : ERC Young Investigator Award
Pays : International
Organisme : Vetenskapsrådet (SE)
ID : Distinguished professorship
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