Variations in cag pathogenicity island genes of Helicobacter pylori from Latin American groups may influence neoplastic progression to gastric cancer.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 04 2020
Historique:
received: 31 07 2018
accepted: 20 03 2020
entrez: 18 4 2020
pubmed: 18 4 2020
medline: 26 11 2020
Statut: epublish

Résumé

Helicobacter pylori (HP) colonizes the human stomach and induces acute gastritis, peptic ulcer disease, atrophic gastritis, and gastric adenocarcinoma. Increased virulence in HP isolates derives from harboring the cag (cytotoxin-associated genes) pathogenicity island (cagPAI). We analyzed the microvariants in cagPAI genes with the hypothesis that they may play an important role in determining HP virulence. We tested DNAs from cagA positive patients HP isolates; a total of 74 patients with chronic gastritis (CG, N = 37), intestinal metaplasia (IM, N = 21) or gastric cancer (GC, N = 16) from Mexico and Colombia. We selected 520 non-synonymous variants with at least 7.5% frequency in the original sequence outputs or with a minimum of 5 isolates with minor allele. After adjustment for multiple comparisons, no variants were statistically significantly associated with IM or GC. However, 19 non-synonymous showed conventional P-values < 0.05 comparing the frequency of the alleles between the isolates from subjects with gastritis and isolates from subjects with IM or GC; 12 of these showed a significant correlation with the severity of the disease. The present study revealed that several cagPAI genes from Latin American Western HP strains contains a number of non-synonymous variants in relatively high frequencies which could influence on the clinical outcome. However, none of the associations remained statistically significant after adjustment for multiple comparison.

Identifiants

pubmed: 32300197
doi: 10.1038/s41598-020-63463-0
pii: 10.1038/s41598-020-63463-0
pmc: PMC7162905
doi:

Types de publication

Journal Article Research Support, N.I.H., Extramural

Langues

eng

Sous-ensembles de citation

IM

Pagination

6570

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Auteurs

Cosmeri Rizzato (C)

Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy. cosmeri.rizzato@unipi.it.

Javier Torres (J)

Unidad de Investigación en Enfermedades Infecciosas, UMAE Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Ofure Obazee (O)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Margarita Camorlinga-Ponce (M)

Unidad de Investigación en Enfermedades Infecciosas, UMAE Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico.

Esperanza Trujillo (E)

Grupo de Investigación en Biología del Cáncer. Instituto Nacional de Cancerología, Bogotá, Colombia.

Angelika Stein (A)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Alfonso Mendez-Tenorio (A)

Laboratorio de Biotecnología y Bioinformática Genómica, ENCB, Instituto Politécnico Nacional, México City, México.

Maria Mercedes Bravo (MM)

Grupo de Investigación en Biología del Cáncer. Instituto Nacional de Cancerología, Bogotá, Colombia.

Federico Canzian (F)

Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany.

Ikuko Kato (I)

Department of Oncology and Pathology, Wayne State University School of Medicine, Detroit, MI, USA.

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