T Lymphocytes in Acute Kidney Injury and Repair.

Acute Kidney Injury / immunology Adaptive Immunity / immunology Animals CD4-Positive T-Lymphocytes / immunology CD8-Positive T-Lymphocytes / immunology Cytokines / immunology Disease Progression Humans Immunity, Innate Inflammation / immunology Intraepithelial Lymphocytes / immunology Kidney / physiology Natural Killer T-Cells / immunology Recovery of Function / immunology Regeneration / immunology Renal Insufficiency, Chronic / immunology Reperfusion Injury / immunology T-Lymphocyte Subsets / immunology T-Lymphocytes / immunology T-Lymphocytes, Regulatory / immunology Th1 Cells / immunology Th2 Cells / immunology
Acute kidney injury T cells immune system ischemia reperfusion repair

Journal

Seminars in nephrology
ISSN: 1558-4488
Titre abrégé: Semin Nephrol
Pays: United States
ID NLM: 8110298

Informations de publication

Date de publication:
03 2020
Historique:
entrez: 19 4 2020
pubmed: 19 4 2020
medline: 4 5 2021
Statut: ppublish

Résumé

Innate and adaptive immune systems participate in the pathogenesis of acute kidney injury (AKI). Considerable data from different research teams have shown the importance of T lymphocytes in the pathophysiology of AKI and, more recently, prevention and repair. T cells can generate or resolve inflammation by secreting specific cytokines and growth factors as well as interact with other immune and stromal cells to induce kidney injury or promote tissue repair. There also are emerging data on the role of T cells in the progression of AKI to chronic kidney disease and organ cross-talk in AKI. These data set the stage for immunomodulatory therapies for AKI. This review focuses on the major populations of T lymphocytes and their roles as mediators for AKI and repair.

Identifiants

DOI: 10.1016/j.semnephrol.2020.01.003 PMID: 32303275
pubmed: 32303275
pii: S0270-9295(20)30003-6
doi: 10.1016/j.semnephrol.2020.01.003
pii:
doi:

Substances chimiques

Cytokines 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

114-125

Subventions

Organisme : NIDDK NIH HHS
ID : R01 DK104662
Pays : United States
Organisme : NIDDK NIH HHS
ID : R01 DK111209
Pays : United States

Informations de copyright

Copyright © 2020 Elsevier Inc. All rights reserved.

Auteurs

Somayeh Gharaie Fathabad (S)

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.

Johanna T Kurzhagen (JT)

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.

Mohanraj Sadasivam (M)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Sanjeev Noel (S)

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD.

Errol Bush (E)

Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.

Abdel R A Hamad (ARA)

Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD.

Hamid Rabb (H)

Division of Nephrology, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: hrabb1@jhmi.edu.

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Classifications MeSH

questionsmedicales.fr › Maladies urogénitales › Maladies urologiques › Maladies du rein › Insuffisance rénale › Atteinte rénale aigüe › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité acquise › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Eucaryotes › Animaux › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD4+ › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Lymphocytes T CD8+ › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Évolution de la maladie › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Phénomènes du système immunitaire › Immunité › Immunité innée › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes intra-épithéliaux › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Appareil urogénital › Voies urinaires › Rein › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Cellules T tueuses naturelles › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Phénomènes biologiques › Récupération fonctionnelle › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Phénomènes biologiques › Régénération › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie chronique › Insuffisance rénale chronique › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Complications postopératoires › Lésion d'ischémie-reperfusion › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th1 › T Lymphocytes in Acute Kidney Injury and Repair.
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Lymphocytes auxiliaires Th2 › T Lymphocytes in Acute Kidney Injury and Repair.