LecB, a High Affinity Soluble Fucose-Binding Lectin from Pseudomonas aeruginosa.
Blood-group oligosaccharide
Fucose
Microcalorimetry
Pseudomonas aeruginosa
Soluble lectin
Journal
Methods in molecular biology (Clifton, N.J.)
ISSN: 1940-6029
Titre abrégé: Methods Mol Biol
Pays: United States
ID NLM: 9214969
Informations de publication
Date de publication:
2020
2020
Historique:
entrez:
20
4
2020
pubmed:
20
4
2020
medline:
9
3
2021
Statut:
ppublish
Résumé
LecB/PA-IIL (Pfam PF07472) from bacterium Pseudomonas aeruginosa is a fucose-binding lectin with unusual high affinity for glycans. The occurrence of LecB and related proteins is limited to few opportunistic bacterial species, some of them being responsible for severe infections in immune-compromised patients. This lectin is therefore of interest as a target for the design of anti-infectious compounds, but can also be used for research and biotechnology. LecB is a small protein that can be produced in good quantity in recombinant system and purified by affinity chromatography.
Identifiants
pubmed: 32306354
doi: 10.1007/978-1-0716-0430-4_46
doi:
Substances chimiques
LecB protein, Pseudomonas aeruginosa
0
Lectins
0
Recombinant Proteins
0
Fucose
28RYY2IV3F
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM