Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase.

Amaryllidaceae / chemistry Amaryllidaceae Alkaloids / chemical synthesis Blood-Brain Barrier Butyrylcholinesterase / drug effects Cholinesterase Inhibitors / chemical synthesis Esters Humans Models, Molecular Molecular Docking Simulation Molecular Structure Substrate Specificity

Journal

Journal of natural products
ISSN: 1520-6025
Titre abrégé: J Nat Prod
Pays: United States
ID NLM: 7906882

Informations de publication

Date de publication:
22 05 2020
Historique:
pubmed: 21 4 2020
medline: 13 7 2021
entrez: 21 4 2020
Statut: ppublish

Résumé

A total of 20 derivatives (

Identifiants

DOI: 10.1021/acs.jnatprod.9b00561 PMID: 32309949
pubmed: 32309949
doi: 10.1021/acs.jnatprod.9b00561
doi:

Substances chimiques

Amaryllidaceae Alkaloids 0
Cholinesterase Inhibitors 0
Esters 0
Butyrylcholinesterase EC 3.1.1.8

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1359-1367

Auteurs

Jana Maříková (J)

ORCID: 0000-0001-9758-2067

Aneta Ritomská (A)

Jan Korábečný (J)

Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.
ORCID: 0000-0001-6977-7596

Rozálie Peřinová (R)

Abdullah Al Mamun (A)

Tomáš Kučera (T)

Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
ORCID: 0000-0002-7399-3993

Eliška Kohelová (E)

Daniela Hulcová (D)

Tereza Kobrlová (T)

Department of Toxicology and Military Pharmacy, Faculty of Military Health Sciences, University of Defence, Trebesska 1575, 500 01 Hradec Kralove, Czech Republic.
Biomedical Research Centre, University Hospital Hradec Kralove, Sokolska 581, 500 05 Hradec Kralove, Czech Republic.

Jiří Kuneš (J)

ORCID: 0000-0001-7257-0641

Lucie Nováková (L)

Lucie Cahlíková (L)

ORCID: 0000-0002-1555-8870

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Classifications MeSH

questionsmedicales.fr › Eucaryotes › Viridiplantae › Streptophyta › Embryophyta › Tracheobionta › Magnoliopsida › Lilianae › Asparagales › Amaryllidaceae › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Composés hétérocycliques › Alcaloïdes › Alcaloïdes des Amaryllidaceae › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Système nerveux › Système nerveux central › Encéphale › Barrière hémato-encéphalique › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Esterases › Carboxylic ester hydrolases › Cholinesterases › Butyrylcholine esterase › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Anticholinestérasiques › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Composés chimiques organiques › Acides carboxyliques › Esters › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Techniques d'investigation › Modèles théoriques › Modèles moléculaires › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Aromatic Esters of the Crinane Amaryllidaceae...
questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Spécificité du substrat › Aromatic Esters of the Crinane Amaryllidaceae...