A rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae with an untypeable bla

Acute Disease Carbapenems / pharmacology Humans Klebsiella Infections Klebsiella pneumoniae / genetics Pancreatitis Phylogeny Plasmids / genetics beta-Lactamases / genetics
Antimicrobial resistance Carbapenem-resistant hypervirulent Klebsiella pneumoniae (CR-HvKP) Horizontal gene transfer (HGT) Mobile genetic elements (MGEs) Transposon

Journal

Journal of global antimicrobial resistance
ISSN: 2213-7173
Titre abrégé: J Glob Antimicrob Resist
Pays: Netherlands
ID NLM: 101622459

Informations de publication

Date de publication:
09 2020
Historique:
received: 28 02 2020
revised: 24 03 2020
accepted: 05 04 2020
pubmed: 21 4 2020
medline: 24 6 2021
entrez: 21 4 2020
Statut: ppublish

Résumé

We investigated the pathogenesis of a patient with severe acute pancreatitis by comprehensively analysing a rare carbapenem-resistant hypervirulent K1/ST1265 Klebsiella pneumoniae (CR-HvKP) strain. We conducted virulence and multidrug-resistance phenotypic characterization and identified a CR-HvKP strain from the patient. It was subjected to Pacbio sequencing, and subsequent analysis of virulence, resistance genes and mobile genetic elements. We described the phenotype and genotype of a rare CR-HvKP strain with an untypeable bla Our research, to our knowledge, first reported a ST1265/K1 CR-HvKP strain with an untypeable bla

Identifiants

DOI: 10.1016/j.jgar.2020.04.009 PMID: 32311501
pubmed: 32311501
pii: S2213-7165(20)30099-0
doi: 10.1016/j.jgar.2020.04.009
pii:
doi:

Substances chimiques

Carbapenems 0
beta-Lactamases EC 3.5.2.6

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

426-433

Informations de copyright

Copyright © 2020 The Author(s). Published by Elsevier Ltd.. All rights reserved.

Auteurs

Cuidan Li (C)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.

Guannan Ma (G)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China.

Tingting Yang (T)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.

Xiaoyu Wen (X)

Department of Hepatology, The First Hospital of Jilin University, Changchun, China.

Chuan Qin (C)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.

Liya Yue (L)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China.

Xinmiao Jia (X)

Central Research Laboratory, Peking Union Medical College Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China.

Yicheng Shen (Y)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.

Dandan Lu (D)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China.

Lifeng Wang (L)

Center of Clinical Laboratory Medicine, Chinese General Hospital of PLA, Beijing, China.

Dingxia Shen (D)

Center of Clinical Laboratory Medicine, Chinese General Hospital of PLA, Beijing, China. Electronic address: shendingxia301@163.com.

Fei Chen (F)

CAS Key Laboratory of Genome Sciences & Information, Beijing Institute of Genomics, Chinese Academy of Sciences, China National Center for Bioinformation, Beijing, China; University of Chinese Academy of Sciences, Beijing, China. Electronic address: chenfei@big.ac.cn.

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Classifications MeSH

questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Caractéristiques de la maladie › Maladie aigüe › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › bêta-Lactames › Carbapénèmes › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Infection › Infections bactériennes et mycoses › Infections bactériennes › Infections bactériennes à Gram négatif › Infections à Enterobacteriaceae › Infections à Klebsiella › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Bactéries › Proteobacteria › Gammaproteobacteria › Enterobacteriaceae › Klebsiella › Klebsiella pneumoniae › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Maladies de l'appareil digestif › Maladies du pancréas › Pancréatite › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Sciences de l'information › Phylogenèse › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Plasmides › A rare carbapenem-resistant hypervirulent...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Amidohydrolases › bêta-Lactamases › A rare carbapenem-resistant hypervirulent...