Neural and behavioral measures suggest that cognitive and affective functioning interactions mediate risk for psychosis-proneness symptoms in youth with chromosome 22q11.2 deletion syndrome.
Abnormalities, Multiple
/ psychology
Adolescent
Case-Control Studies
Child
Chromosome Deletion
Chromosomes, Human, Pair 22
Cognitive Dysfunction
/ genetics
DiGeorge Syndrome
/ psychology
Electroencephalography
Emotions
Evoked Potentials
Executive Function
/ physiology
Female
Humans
Male
Psychotic Disorders
/ genetics
22q11.2 deletion
emotion regulation
event-related potentials (ERP)
executive function
psychosis
Journal
American journal of medical genetics. Part A
ISSN: 1552-4833
Titre abrégé: Am J Med Genet A
Pays: United States
ID NLM: 101235741
Informations de publication
Date de publication:
07 2020
07 2020
Historique:
received:
31
10
2019
revised:
04
03
2020
accepted:
01
04
2020
pubmed:
23
4
2020
medline:
10
3
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
Behavioral components of chromosome 22q11.2 deletion syndrome (22q), caused by the most common human microdeletion, include cognitive and adaptive functioning impairments, heightened anxiety, and an elevated risk of schizophrenia. We investigated how interactions between executive function and the largely overlooked factor of emotion regulation might relate to the incidence of symptoms of psychotic thinking in youth with 22q. We measured neural activity with event-related potentials (ERPs) in variants of an inhibitory function (Go/No-Go) experimental paradigm that presented affective or non-affective stimuli. The study replicated inhibition impairments in the 22q group that were amplified in the presence of stimuli with negative, more than positive affective salience. Importantly, the anterior N2 conflict monitoring ERP significantly increased when youth with 22q viewed angry and happy facial expressions, unlike the typically developing participants. This suggests that youth with 22q may require greater conflict monitoring resources when controlling their behavior in response to highly salient social signals. This evidence of both behavioral and neurophysiological differences in affectively influenced inhibitory function suggests that frequently anxious youth with 22q may struggle more with cognitive control in emotionally charged social settings, which could influence their risk of developing symptoms of psychosis.
Identifiants
pubmed: 32319730
doi: 10.1002/ajmg.a.61596
pmc: PMC9196260
mid: NIHMS1794655
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1615-1630Subventions
Organisme : NICHD NIH HHS
ID : P50 HD103526
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH107108
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD079125
Pays : United States
Organisme : NIH HHS
ID : R01-MH107018
Pays : United States
Informations de copyright
© 2020 Wiley Periodicals, Inc.
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