Effects of single green tea ingestion on pharmacokinetics of nadolol in healthy volunteers.
epigallocatechin gallate
food-drug interaction
green tea
nadolol
pharmacokinetics
Journal
British journal of clinical pharmacology
ISSN: 1365-2125
Titre abrégé: Br J Clin Pharmacol
Pays: England
ID NLM: 7503323
Informations de publication
Date de publication:
11 2020
11 2020
Historique:
received:
01
12
2019
revised:
19
03
2020
accepted:
02
04
2020
pubmed:
23
4
2020
medline:
29
7
2021
entrez:
23
4
2020
Statut:
ppublish
Résumé
The aim of this study was to investigate the effects of a single green tea (GT), administered concomitantly or 1 hour before nadolol intake on nadolol pharmacokinetics. In a randomized 3-phase crossover study, 11 healthy volunteers received an oral administration of nadolol with, or 1 hour after preingestion of brewed GT, or with water in a volume of 150 mL. Geometric mean ratio with 90% confidence interval for nadolol AUC These results suggest that single concomitant ingestion of GT substantially decreases plasma concentrations of nadolol. Moreover, the reduction in nadolol bioavailability could persist for at least 1 hour after drinking a cup of GT.
Identifiants
pubmed: 32320490
doi: 10.1111/bcp.14315
pmc: PMC7576630
doi:
Substances chimiques
Tea
0
Nadolol
42200-33-9
Catechin
8R1V1STN48
Types de publication
Clinical Trial, Phase III
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
2314-2318Subventions
Organisme : JSPS KAKENHI
ID : JP17K17983
Organisme : Honjo International Scholarship Foundation (Food and Health Program 2015), Tokyo, Japan
Informations de copyright
© 2020 The British Pharmacological Society.
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