Paraneoplastic cerebellar degeneration in a patient with breast cancer associated with carbonic anhydrase-related protein VIII autoantibodies.
Breast cancer
Carbonic anhydrase-related protein VIII
Paraneoplastic cerebellar degeneration
Journal
Journal of neuroimmunology
ISSN: 1872-8421
Titre abrégé: J Neuroimmunol
Pays: Netherlands
ID NLM: 8109498
Informations de publication
Date de publication:
15 07 2020
15 07 2020
Historique:
received:
28
03
2020
accepted:
13
04
2020
pubmed:
24
4
2020
medline:
12
11
2020
entrez:
24
4
2020
Statut:
ppublish
Résumé
Paraneoplastic cerebellar degeneration is a neurological syndrome resulting from immune-mediated dysfunction of Purkinje cells and commonly is associated with a tumor. In most cases, well-characterized onconeural antibodies are detected, such as anti-Yo and anti-Ri antibodies. Carbonic anhydrase-related protein VIII (CARP VIII) antibodies associated with paraneoplastic cerebellar degeneration have been previously described in only two cases. Herein, we present a 75-year-old female who developed progressive cerebellar ataxia. Anti-CARP VIII autoantibodies were found at high titres and screening for underlying malignancies revealed a breast cancer. Intravenous immunoglobulin was administered with poor results. Our report further confirms the role of CARP VIII antibodies in cerebellar degeneration.
Identifiants
pubmed: 32325285
pii: S0165-5728(20)30197-1
doi: 10.1016/j.jneuroim.2020.577242
pii:
doi:
Substances chimiques
Autoantibodies
0
Biomarkers, Tumor
0
CA8 protein, human
EC 4.2.1.1
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
577242Informations de copyright
Copyright © 2020 Elsevier B.V. All rights reserved.