New Therapeutic Strategies for Osteoarthritis by Targeting Sialic Acid Receptors.
Animals
Cartilage, Articular
/ metabolism
Cells, Cultured
Chondrocytes
/ metabolism
Extracellular Matrix
/ metabolism
Female
Glycoproteins
/ chemistry
Humans
Lectins
/ metabolism
Male
Membrane Glycoproteins
/ metabolism
Mice, Inbred BALB C
Models, Molecular
N-Acetylneuraminic Acid
/ metabolism
NF-kappa B
/ metabolism
Osteoarthritis
/ pathology
Protein Binding
Protein Isoforms
/ metabolism
Receptors, Cell Surface
/ metabolism
Signal Transduction
MASL
arthritis
articular chondrocyte
cartilage
glycoproteins
molecular modelling
osteoarthritis
podoplanin
sialylation
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
21 04 2020
21 04 2020
Historique:
received:
20
03
2020
revised:
12
04
2020
accepted:
14
04
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
7
4
2021
Statut:
epublish
Résumé
Osteoarthritis (OA) is the most common degenerative joint disease characterized by articular cartilage degradation and joint degeneration. The articular cartilage is mainly formed by chondrocytes and a collagen-proteoglycan extracellular matrix that contains high levels of glycosylated proteins. It was reported that the shift from glycoproteins containing α-2,6-linked sialic acids to those that contain α-2,3 was associated with the onset of common types of arthritis. However, the pathophysiology of α-2,3-sialylation in cartilage has not been yet elucidated. We show that cartilage from osteoarthritic patients expresses high levels of the α-2,3-sialylated transmembrane mucin receptor, known as podoplanin (PDPN). Additionally, the
Identifiants
pubmed: 32326143
pii: biom10040637
doi: 10.3390/biom10040637
pmc: PMC7226619
pii:
doi:
Substances chimiques
Glycoproteins
0
Lectins
0
Membrane Glycoproteins
0
NF-kappa B
0
PDPN protein, human
0
Protein Isoforms
0
Receptors, Cell Surface
0
sialic acid receptor
0
N-Acetylneuraminic Acid
GZP2782OP0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Sociedad Española de Reumatología
ID : FER-2013
Pays : International
Organisme : Spanish Society for Research on Bone and Mineral Metabolism
ID : FEIOMM-2016
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI13/00591
Pays : International
Organisme : Instituto de Salud Carlos III
ID : PI16/00035
Pays : International
Organisme : Ministerio de Economía, Industria y Competitividad, Gobierno de España
ID : CTQ2017-88353-R
Pays : International
Références
Oncotarget. 2015 Apr 20;6(11):9045-60
pubmed: 25826087
Nat Protoc. 2015 Jun;10(6):845-58
pubmed: 25950237
PLoS One. 2012;7(7):e41845
pubmed: 22844530
Mol Cancer. 2013 Dec 20;12(1):168
pubmed: 24354864
Oncogene. 2015 Aug 20;34(34):4531-44
pubmed: 25486435
Histochem Cell Biol. 2014 Oct;142(4):373-88
pubmed: 24981556
Glycoconj J. 1994 Dec;11(6):572-5
pubmed: 7696860
FEBS Lett. 2007 Jan 23;581(2):331-6
pubmed: 17222411
Nat Rev Drug Discov. 2005 Jun;4(6):477-88
pubmed: 15931257
Front Immunol. 2012 Sep 12;3:283
pubmed: 22988448
Nat Rev Immunol. 2009 May;9(5):338-52
pubmed: 19365409
PLoS One. 2014 Jun 16;9(6):e99607
pubmed: 24932813
Adv Carbohydr Chem Biochem. 1982;40:131-234
pubmed: 6762816
Front Biosci. 2008 Jan 01;13:1130-40
pubmed: 17981618
Structure. 2014 Dec 2;22(12):1711-1721
pubmed: 25458834
Oncotarget. 2015 Nov 3;6(34):36003-18
pubmed: 26416352
J Immunotoxicol. 2016 Sep;13(5):652-65
pubmed: 27075513
Mol Immunol. 2013 Jun;54(2):199-207
pubmed: 23287598
Glycoconj J. 1997 Jun;14(4):449-56
pubmed: 9249142
Am J Pathol. 2013 Apr;182(4):1337-46
pubmed: 23416160
J Mol Biol. 2000 Sep 8;302(1):205-17
pubmed: 10964570
J Biol Chem. 1988 Apr 5;263(10):4576-85
pubmed: 3350806
J Thromb Haemost. 2010 Jul;8(7):1456-67
pubmed: 20345705
RMD Open. 2015 Aug 15;1(Suppl 1):e000061
pubmed: 26557379
Ann Rheum Dis. 2015 Jan;74(1):275-84
pubmed: 24225059
Trends Immunol. 2018 Jul;39(7):523-535
pubmed: 29759949
Br J Cancer. 2007 Jan 15;96(1):1-5
pubmed: 17179989
Cancer Metastasis Rev. 2012 Dec;31(3-4):501-18
pubmed: 22699311
Eur J Immunol. 2015 Aug;45(8):2218-31
pubmed: 25973789
J Thromb Haemost. 2011 Jul;9 Suppl 1:44-55
pubmed: 21781241
Eur J Immunol. 2011 Oct;41(10):3040-53
pubmed: 21728173
Pathol Res Pract. 2012 Mar 15;208(3):140-6
pubmed: 22326634
Nat Rev Immunol. 2018 Mar;18(3):204-211
pubmed: 29398707
Exp Cell Res. 2009 Jun 10;315(10):1715-23
pubmed: 19268462
FEBS Lett. 1994 Apr 11;342(3):334-8
pubmed: 8150094
Blood. 2010 Jul 29;116(4):661-70
pubmed: 20363774
Osteoarthritis Cartilage. 2010 Feb;18(2):240-8
pubmed: 19800998
Mol Cell. 1999 Dec;4(6):1029-40
pubmed: 10635327
J Biol Chem. 1993 Jun 25;268(18):13237-41
pubmed: 7685757
Am J Med Sci. 2012 Dec;344(6):486-90
pubmed: 22885622
J Biol Chem. 2013 Apr 26;288(17):12215-21
pubmed: 23530051
Biochimie. 2001 Aug;83(8):727-37
pubmed: 11530204
Sci Rep. 2016 May 09;6:25463
pubmed: 27157803
Int J Surg Pathol. 2013 Dec;21(6):587-90
pubmed: 23816822
Nat Struct Mol Biol. 2009 Nov;16(11):1186-8
pubmed: 19820709
Genes Dev. 2000 Oct 15;14(20):2610-22
pubmed: 11040215
Clin Chim Acta. 1992 Jun 30;208(3):149-71
pubmed: 1499135
Biochim Biophys Acta. 2015 Jan;1850(1):186-235
pubmed: 24685397
Glycobiology. 2011 Aug;21(8):988-93
pubmed: 21863598
Carbohydr Res. 2010 Jul 2;345(10):1389-93
pubmed: 20303074
J Oral Sci. 2012 Sep;54(3):241-50
pubmed: 23047035
J Biochem. 1997 Apr;121(4):756-61
pubmed: 9163528
Int J Radiat Oncol Biol Phys. 2015 Mar 1;91(3):640-9
pubmed: 25596111
Osteoarthritis Cartilage. 2010 Oct;18 Suppl 3:S17-23
pubmed: 20864019
J Biol Chem. 1974 May 10;249(9):2786-92
pubmed: 4828319
Exp Cell Res. 2015 Jul 1;335(1):115-22
pubmed: 25959509
J Immunol. 2016 Feb 15;196(4):1910-21
pubmed: 26792806
Cold Spring Harb Perspect Biol. 2009 Dec;1(6):a001651
pubmed: 20457564
J Biol Chem. 2000 Jun 9;275(23):17541-8
pubmed: 10747930
J Biol Chem. 1991 Jan 5;266(1):83-8
pubmed: 1985926
Arthritis Res Ther. 2013 Oct 04;15(5):R147
pubmed: 24289744
Int Rev Cell Mol Biol. 2015;317:185-239
pubmed: 26008786
Free Radic Res. 2012 Dec;46(12):1482-9
pubmed: 22998065
Osteoarthritis Cartilage. 1997 Sep;5(5):301-8
pubmed: 9497937
Arthritis Rheum. 2012 Jun;64(6):1697-707
pubmed: 22392533
Nat Rev Mol Cell Biol. 2012 Jun 22;13(7):448-62
pubmed: 22722607
Int J Biochem Cell Biol. 2013 Nov;45(11):2580-4
pubmed: 24004831
Cancer Lett. 2007 Aug 8;253(1):25-33
pubmed: 17207926
Nat Rev Rheumatol. 2016 Mar;12(3):132
pubmed: 26841688
Trends Biochem Sci. 2015 Jul;40(7):341
pubmed: 26006324
Arthritis Res Ther. 2011 Mar 07;13(2):R40
pubmed: 21385358
Nat Commun. 2016 Apr 12;7:11302
pubmed: 27066737
J Dermatol Sci. 2012 Feb;65(2):134-40
pubmed: 22189341