Sex chromosome evolution in parasitic nematodes of humans.
Animals
Brugia malayi
/ genetics
Caenorhabditis elegans
/ genetics
Chromosome Mapping
Evolution, Molecular
Female
Gene Expression Regulation
Genome, Helminth
/ genetics
Humans
Male
Nematoda
/ classification
Nematode Infections
/ parasitology
Repetitive Sequences, Nucleic Acid
/ genetics
Sex Chromosomes
/ genetics
Sex Determination Processes
/ genetics
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
23 04 2020
23 04 2020
Historique:
received:
31
07
2019
accepted:
20
03
2020
entrez:
25
4
2020
pubmed:
25
4
2020
medline:
1
8
2020
Statut:
epublish
Résumé
Sex determination mechanisms often differ even between related species yet the evolution of sex chromosomes remains poorly understood in all but a few model organisms. Some nematodes such as Caenorhabditis elegans have an XO sex determination system while others, such as the filarial parasite Brugia malayi, have an XY mechanism. We present a complete B. malayi genome assembly and define Nigon elements shared with C. elegans, which we then map to the genomes of other filarial species and more distantly related nematodes. We find a remarkable plasticity in sex chromosome evolution with several distinct cases of neo-X and neo-Y formation, X-added regions, and conversion of autosomes to sex chromosomes from which we propose a model of chromosome evolution across different nematode clades. The phylum Nematoda offers a new and innovative system for gaining a deeper understanding of sex chromosome evolution.
Identifiants
pubmed: 32327641
doi: 10.1038/s41467-020-15654-6
pii: 10.1038/s41467-020-15654-6
pmc: PMC7181701
doi:
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1964Subventions
Organisme : Wellcome Trust
ID : 098051
Pays : United Kingdom
Organisme : NIAID NIH HHS
ID : U19 AI110820
Pays : United States
Organisme : Medical Research Council
ID : MR/L001020/1
Pays : United Kingdom
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