Palladium-Catalyzed C-4 Selective Coupling of 2,4-Dichloropyridines and Synthesis of Pyridine-Based Dyes for Live-Cell Imaging.
Journal
The Journal of organic chemistry
ISSN: 1520-6904
Titre abrégé: J Org Chem
Pays: United States
ID NLM: 2985193R
Informations de publication
Date de publication:
15 05 2020
15 05 2020
Historique:
pubmed:
25
4
2020
medline:
1
6
2021
entrez:
25
4
2020
Statut:
ppublish
Résumé
An alternative process of Pd-catalyzed C-4 selective coupling of 2,4-dichloropyridines with boronic esters was developed, which afforded 24 examples of C-4 coupled pyridines in moderate to good yields. After further arylation, 21 examples of C-2, C-4 diarylated pyridines with a significant photophysical property were obtained, which were applied as pyridine-based dyes into live-cell imaging with good biocompatibility and low toxicity.
Identifiants
pubmed: 32329338
doi: 10.1021/acs.joc.0c00449
doi:
Substances chimiques
Coloring Agents
0
Pyridines
0
Palladium
5TWQ1V240M
pyridine
NH9L3PP67S
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM