Role of Endocannabinoids in Energy-Balance Regulation in Participants in the Postobese State-a PREVIEW Study.
adiposity
endocannabinoids
energy balance
protein
Journal
The Journal of clinical endocrinology and metabolism
ISSN: 1945-7197
Titre abrégé: J Clin Endocrinol Metab
Pays: United States
ID NLM: 0375362
Informations de publication
Date de publication:
01 07 2020
01 07 2020
Historique:
received:
10
01
2020
accepted:
21
04
2020
pubmed:
26
4
2020
medline:
9
2
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Endocannabinoids are suggested to play a role in energy balance regulation. We aimed to investigate associations of endocannabinoid concentrations during the day with energy balance and adiposity and interactions with 2 diets differing in protein content in participants in the postobese phase with prediabetes. Participants (n = 38) were individually fed in energy balance with a medium protein (MP: 15:55:30% of energy from protein:carbohydrate:fat) or high-protein diet (HP: 25:45:30% energy from P:C:F) for 48 hours in a respiration chamber. Associations between energy balance, energy expenditure, respiratory quotient, and endocannabinoid concentrations during the day were assessed. Plasma-concentrations of anandamide (AEA), oleoylethanolamide (OEA), palmitoyethanolamide (PEA), and pregnenolone (PREG) significantly decreased during the day. This decrease was inversely related to body mass index (AEA) or body fat (%) (PEA; OEA). The lowest RQ value, before lunch, was inversely associated with concentrations of AEA and PEA before lunch. Area under the curve (AUC) of concentrations of AEA, 2-AG, PEA, and OEA were positively related to body fat% (P < .05).The HP and MP groups showed no differences in concentrations of AEA, OEA, PEA, and PREG, but the AUC of 2-arachidonoylglycerol (2-AG) was significantly higher in the HP vs the MP group. In energy balance, only the endocannabinoid 2-AG changed in relation to protein level of the diet, whereas the endocannabinoid AEA and endocannabinoid-related compounds OEA and PEA reflected the gradual energy intake matching energy expenditure during the day.
Identifiants
pubmed: 32333763
pii: 5825220
doi: 10.1210/clinem/dgaa193
pmc: PMC7247554
pii:
doi:
Substances chimiques
Aldehydes
0
Arachidonic Acids
0
Endocannabinoids
0
Oleic Acids
0
Polyunsaturated Alkamides
0
oleoylethanolamide
1HI5J9N8E6
Pregnenolone
73R90F7MQ8
anandamide
UR5G69TJKH
hexadecanal
WQD27655QE
Banques de données
ClinicalTrials.gov
['NCT01777893']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
Published by Oxford University Press on behalf of the Endocrine Society 2020.
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