Reperfusion combined with intraarterial administration of resveratrol-loaded nanoparticles improved cerebral ischemia-reperfusion injury in rats.
Animals
Antioxidants
/ therapeutic use
Brain Ischemia
/ drug therapy
Brain-Derived Neurotrophic Factor
/ metabolism
Infarction, Middle Cerebral Artery
/ drug therapy
Infusions, Intra-Arterial
Male
Nanoparticles
/ chemistry
Oxidative Stress
/ drug effects
Rats
Rats, Sprague-Dawley
Reperfusion Injury
/ drug therapy
Resveratrol
/ chemistry
Stroke
/ drug therapy
Nanoparticle
Reperfusion
Resveratrol
Stroke
Journal
Nanomedicine : nanotechnology, biology, and medicine
ISSN: 1549-9642
Titre abrégé: Nanomedicine
Pays: United States
ID NLM: 101233142
Informations de publication
Date de publication:
08 2020
08 2020
Historique:
received:
08
10
2019
revised:
13
03
2020
accepted:
28
03
2020
pubmed:
26
4
2020
medline:
16
7
2021
entrez:
26
4
2020
Statut:
ppublish
Résumé
Endovascular thrombectomy (EVT) has been recommended as the first line therapy for large artery occlusion (LAO) stroke. However, abrupt recovery of blood flow induces oxidative stress which breaks down the blood-brain barrier (BBB), activates apoptosis and inhibits neurogenesis. Supplement of exogenous antioxidants to relieve the injuries related to oxidative stress is a rational treatment combined to EVT for acute LAO therapy. Resveratrol (RES), an antioxidant, was encapsulated into polymeric nanoparticles (RES-NPs). In transient middle cerebral artery occlusion (tMCAO) rats, intraarterial administration of RES-NPs demonstrated significant protection against cerebral ischemia/reperfusion (I/R) injuries. RES-NPs attenuated the oxidative stress induced by I/R, prevented brain edema, protected neurons from undergoing apoptosis, and contributed to neurogenesis through enhanced expression of brain-derived neurotrophic factor (BDNF). These results suggested that intra-arterial infusion of RES-NPs in conjunction with EVT could be a potential strategy for the LAO stroke therapy.
Identifiants
pubmed: 32334100
pii: S1549-9634(20)30062-9
doi: 10.1016/j.nano.2020.102208
pii:
doi:
Substances chimiques
Antioxidants
0
Brain-Derived Neurotrophic Factor
0
Resveratrol
Q369O8926L
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
102208Informations de copyright
Copyright © 2020 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Conflict of interest The authors report no conflicts of interest.