Emerging genetic diversity among clinical isolates of SARS-CoV-2: Lessons for today.
COVID-19
Coronavirus
Molecular divergence
Phylogenetics
SARS-CoV-2
Journal
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases
ISSN: 1567-7257
Titre abrégé: Infect Genet Evol
Pays: Netherlands
ID NLM: 101084138
Informations de publication
Date de publication:
10 2020
10 2020
Historique:
received:
29
03
2020
revised:
21
04
2020
accepted:
22
04
2020
pubmed:
27
4
2020
medline:
12
9
2020
entrez:
27
4
2020
Statut:
ppublish
Résumé
Considering the current pandemic of COVID-19, it is imperative to gauge the role of molecular divergence in SARS-CoV-2 with time, due to clinical and epidemiological concerns. Our analyses involving molecular phylogenetics is a step toward understanding the transmission clusters that can be correlated to pathophysiology of the disease to gain insight into virulence mechanism. As the infections are increasing rapidly, more divergence is expected followed possibly by viral adaptation. We could identify mutational hotspots which appear to be major drivers of diversity among strains, with RBD of spike protein emerging as the key region involved in interaction with ACE2 and consequently a major determinant of infection outcome. We believe that such molecular analyses correlated with clinical characteristics and host predisposition need to be evaluated at the earliest to understand viral adaptability, disease prognosis, and transmission dynamics.
Identifiants
pubmed: 32335334
pii: S1567-1348(20)30161-1
pii: S1567-1348(20)30161-1
doi: 10.1016/j.meegid.2020.104330
pmc: PMC7180377
pii:
doi:
Substances chimiques
Spike Glycoprotein, Coronavirus
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
104330Informations de copyright
© 2020 Published by Elsevier B.V.
Déclaration de conflit d'intérêts
The Authors declare no conflict of interest.
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