A Bioorthogonal Click Chemistry Toolbox for Targeted Synthesis of Branched and Well-Defined Protein-Protein Conjugates.
antibody-drug conjugates
bioorthogonal chemistry
click chemistry
protein ligation
protein-protein conjugates
Journal
Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543
Informations de publication
Date de publication:
27 07 2020
27 07 2020
Historique:
received:
19
12
2019
revised:
23
04
2020
pubmed:
29
4
2020
medline:
27
4
2021
entrez:
29
4
2020
Statut:
ppublish
Résumé
Bioorthogonal chemistry holds great potential to generate difficult-to-access protein-protein conjugate architectures. Current applications are hampered by challenging protein expression systems, slow conjugation chemistry, use of undesirable catalysts, or often do not result in quantitative product formation. Here we present a highly efficient technology for protein functionalization with commonly used bioorthogonal motifs for Diels-Alder cycloaddition with inverse electron demand (DA
Identifiants
pubmed: 32342666
doi: 10.1002/anie.201915079
pmc: PMC7496671
doi:
Substances chimiques
Immunoconjugates
0
Proteins
0
Ligases
EC 6.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
12885-12893Informations de copyright
© 2020 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.
Références
Angew Chem Int Ed Engl. 2013 Dec 23;52(52):14112-6
pubmed: 24281986
Structure. 1997 Aug 15;5(8):997-1015
pubmed: 9309217
J Am Chem Soc. 2004 Nov 24;126(46):15046-7
pubmed: 15547999
Proc Natl Acad Sci U S A. 2014 Apr 1;111(13):E1176-81
pubmed: 24639550
Nat Chem. 2012 Feb 05;4(4):298-304
pubmed: 22437715
J Am Chem Soc. 2012 Feb 15;134(6):2898-901
pubmed: 22283158
Methods Enzymol. 2018;598:283-319
pubmed: 29306439
J Am Chem Soc. 2015 Sep 9;137(35):11461-75
pubmed: 26270632
Org Biomol Chem. 2016 Jun 28;14(24):5606-11
pubmed: 27072883
Angew Chem Int Ed Engl. 2008;47(37):7018-21
pubmed: 18677791
Chembiochem. 2014 Aug 18;15(12):1765-8
pubmed: 25045107
Nano Lett. 2005 Mar;5(3):519-22
pubmed: 15755106
Chemistry. 2015 Aug 24;21(35):12266-70
pubmed: 26177861
Angew Chem Int Ed Engl. 2012 Apr 23;51(17):4166-70
pubmed: 22473599
Bioconjug Chem. 2015 Feb 18;26(2):176-92
pubmed: 25494884
Angew Chem Int Ed Engl. 2012 May 21;51(21):5222-5
pubmed: 22511586
J Am Chem Soc. 2004 Mar 10;126(9):2670-1
pubmed: 14995162
ChemistryOpen. 2019 Mar 28;8(3):354-357
pubmed: 30976476
Angew Chem Int Ed Engl. 2013 Apr 8;52(15):4265-8
pubmed: 23468318
Virology. 2015 Oct;484:412-20
pubmed: 26051211
Proc Natl Acad Sci U S A. 2010 Jun 15;107(24):10914-9
pubmed: 20534555
ACS Chem Biol. 2014 Jan 17;9(1):16-20
pubmed: 24432752
Bioconjug Chem. 2011 Oct 19;22(10):2048-59
pubmed: 21877749
Nat Chem. 2011 Oct 23;3(12):925-31
pubmed: 22109271
Anal Biochem. 2003 Jun 1;317(1):107-15
pubmed: 12729607
Angew Chem Int Ed Engl. 2010 Apr 26;49(19):3375-8
pubmed: 20391522
J Am Chem Soc. 2015 Aug 19;137(32):10044-7
pubmed: 26237426
Bioconjug Chem. 2015 Jun 17;26(6):1104-12
pubmed: 25982177
Proc Natl Acad Sci U S A. 2012 Jul 24;109(30):11993-8
pubmed: 22778432
Tetrahedron. 2019 Aug 9;75(32):4307-4317
pubmed: 32612312
Angew Chem Int Ed Engl. 2011 Apr 18;50(17):3878-81
pubmed: 21433234
Protein Sci. 2005 Sep;14(9):2436-46
pubmed: 16081651
Biochem J. 1978 Sep 1;173(3):723-37
pubmed: 708370
J Am Chem Soc. 2012 Jan 18;134(2):792-5
pubmed: 22176354
Chem Commun (Camb). 2010 Feb 14;46(6):931-3
pubmed: 20107654
Front Mol Neurosci. 2013 Mar 04;6:2
pubmed: 23459413
J Biol Chem. 1992 Oct 5;267(28):20011-6
pubmed: 1400316
Curr Opin Struct Biol. 2016 Jun;38:111-8
pubmed: 27318815
Bioconjug Chem. 2017 Apr 19;28(4):918-922
pubmed: 28267922
Angew Chem Int Ed Engl. 2018 Apr 3;57(15):3949-3953
pubmed: 29437274
Angew Chem Int Ed Engl. 2020 Jul 27;59(31):12885-12893
pubmed: 32342666
Chemistry. 2015 Aug 24;21(35):12431-5
pubmed: 26178299
Bioconjug Chem. 2019 May 15;30(5):1405-1414
pubmed: 30883100
J Struct Biol. 2011 May;174(2):385-90
pubmed: 21335090
J Am Chem Soc. 2008 Oct 15;130(41):13518-9
pubmed: 18798613
Bioconjug Chem. 2014 Jul 16;25(7):1203-12
pubmed: 24946229
ACS Chem Biol. 2018 Aug 17;13(8):2058-2066
pubmed: 29920062
Bioconjug Chem. 2019 Jun 19;30(6):1702-1710
pubmed: 31083974
Br J Cancer. 2016 Feb 16;114(4):362-7
pubmed: 26742008
Angew Chem Int Ed Engl. 2012 Jun 11;51(24):5852-6
pubmed: 22555882
Angew Chem Int Ed Engl. 2016 Nov 2;55(45):14046-14050
pubmed: 27735133
J Biol Chem. 2010 Mar 26;285(13):9971-80
pubmed: 20089862
ACS Comb Sci. 2019 Jul 8;21(7):522-527
pubmed: 31181888
J Am Chem Soc. 2012 Jun 27;134(25):10317-20
pubmed: 22694658
Angew Chem Int Ed Engl. 2018 Mar 5;57(11):2831-2834
pubmed: 29356244
Chembiochem. 2015 May 26;16(8):1158-62
pubmed: 25900689
Angew Chem Int Ed Engl. 2010 Dec 3;49(49):9422-5
pubmed: 20857472
J Am Chem Soc. 2010 Apr 7;132(13):4526-7
pubmed: 20235501
Biochem J. 1993 Jan 1;289 ( Pt 1):81-5
pubmed: 8424775
J Bacteriol. 2003 Mar;185(5):1582-9
pubmed: 12591875
Angew Chem Int Ed Engl. 2012 Jul 23;51(30):7476-9
pubmed: 22696426
Angew Chem Int Ed Engl. 2010 Apr 12;49(17):3065-8
pubmed: 20333639
Bioconjug Chem. 2008 Dec;19(12):2297-9
pubmed: 19053305
Annu Rev Med. 2018 Jan 29;69:191-207
pubmed: 29414262
Chem Soc Rev. 2017 Aug 14;46(16):4895-4950
pubmed: 28660957
Angew Chem Int Ed Engl. 2014 Mar 3;53(10):2662-6
pubmed: 24481645
Vaccine. 1992;10(10):691-8
pubmed: 1523880
Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):1202-7
pubmed: 26787909
Nat Commun. 2018 Jul 23;9(1):2881
pubmed: 30038362