Fast Screening of Whole Blood and Tumor Tissue for Bladder Cancer Biomarkers Using Stochastic Needle Sensors.
E-cadherin
bladder cancer
bladder tumor antigen
hyaluronic acid
p53
stochastic needle sensor
Journal
Sensors (Basel, Switzerland)
ISSN: 1424-8220
Titre abrégé: Sensors (Basel)
Pays: Switzerland
ID NLM: 101204366
Informations de publication
Date de publication:
24 Apr 2020
24 Apr 2020
Historique:
received:
01
03
2020
revised:
12
04
2020
accepted:
23
04
2020
entrez:
30
4
2020
pubmed:
30
4
2020
medline:
5
2
2021
Statut:
epublish
Résumé
Bladder cancer is one of the most common urologic malignancies, which is more frequent in men than in women. The early diagnosis for this type of cancer still remains a challenge, therefore, the development of a fast screening test for whole blood and tumor tissue samples may save lives. Four biomarkers, p53, E-cadherin, bladder tumor antigen (BTA), and hyaluronic acid were considered for the screening tests using stochastic needle sensors. Three stochastic needle sensors, based on graphite powder and modified with three types of chitosan, were designed and characterized for the screening test. The proposed sensors showed low limits of quantification, and high sensitivity and selectivity levels. The recoveries of p53, E-cadherin, BTA, and hyaluronic acid in whole blood samples and tissue samples were higher than 95.00% with a relative standard deviation lower than 1.00%.
Identifiants
pubmed: 32344622
pii: s20082420
doi: 10.3390/s20082420
pmc: PMC7219496
pii:
doi:
Substances chimiques
Antigens, Neoplasm
0
Biomarkers, Tumor
0
Cadherins
0
bladder tumor-associated antigen
0
Hyaluronic Acid
9004-61-9
Chitosan
9012-76-4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
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