Non-Equilibrium Polymerization of Cross-β Amyloid Peptides for Temporal Control of Electronic Properties.


Journal

Angewandte Chemie (International ed. in English)
ISSN: 1521-3773
Titre abrégé: Angew Chem Int Ed Engl
Pays: Germany
ID NLM: 0370543

Informations de publication

Date de publication:
03 08 2020
Historique:
received: 12 03 2020
revised: 13 04 2020
pubmed: 30 4 2020
medline: 27 4 2021
entrez: 30 4 2020
Statut: ppublish

Résumé

Hydrophobic collapse plays crucial roles in protein functions, from accessing the complex three-dimensional structures of native enzymes to the dynamic polymerization of non-equilibrium microtubules. However, hydrophobic collapse can also lead to the thermodynamically downhill aggregation of aberrant proteins, which has interestingly led to the development of a unique class of soft nanomaterials. There remain critical gaps in the understanding of the mechanisms of how hydrophobic collapse can regulate such aggregation. Demonstrated herein is a methodology for non-equilibrium amyloid polymerization through mutations of the core sequence of Aβ peptides by a thermodynamically activated moiety. An out of equilibrium state is realized because of the negative feedback from the transiently formed cross-β amyloid networks. Such non-equilibrium amyloid nanostructures were utilized to access temporal control over its electronic properties.

Identifiants

pubmed: 32348633
doi: 10.1002/anie.202003721
doi:

Substances chimiques

Amyloid beta-Peptides 0
Peptide Fragments 0
amyloid beta-protein (1-42) 0
Histidine 4QD397987E

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

13506-13510

Informations de copyright

© 2020 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Auteurs

Subhajit Bal (S)

Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

Chandranath Ghosh (C)

Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

Tapan Ghosh (T)

Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

Ratheesh K Vijayaraghavan (RK)

Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

Dibyendu Das (D)

Department of Chemical Sciences & Centre for Advanced Functional Materials, Indian Institute of Science Education and Research (IISER), Kolkata, Mohanpur, West Bengal, 741246, India.

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