Prevalence of Cytoplasmic Actin Mutations in Diffuse Large B-Cell Lymphoma and Multiple Myeloma: A Functional Assessment Based on Actin Three-Dimensional Structures.
Actins
/ chemistry
Alleles
Biomarkers, Tumor
Cytoplasm
/ metabolism
Databases, Genetic
Gene Amplification
Gene Deletion
Genetic Association Studies
Genetic Predisposition to Disease
Humans
Lymphoma, Large B-Cell, Diffuse
/ diagnosis
Models, Molecular
Multiple Myeloma
/ diagnosis
Mutation
Mutation Rate
Organ Specificity
Protein Conformation
Software
Structure-Activity Relationship
ACTB
ACTG1
F-actin
actin mutations
cBioPortal
lymphoid cancer
meta-analysis of patient data
myosin
patient cancer data
plasma cell myeloma
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
27 Apr 2020
27 Apr 2020
Historique:
received:
08
04
2020
revised:
24
04
2020
accepted:
26
04
2020
entrez:
1
5
2020
pubmed:
1
5
2020
medline:
2
2
2021
Statut:
epublish
Résumé
Mutations in actins have been linked to several developmental diseases. Their occurrence across different cancers has, however, not been investigated. Using the cBioPortal database we show that human actins are infrequently mutated in patient samples of various cancers types. Nevertheless, ranking these studies by mutational frequency suggest that some have a higher percentage of patients with
Identifiants
pubmed: 32349449
pii: ijms21093093
doi: 10.3390/ijms21093093
pmc: PMC7247664
pii:
doi:
Substances chimiques
Actins
0
Biomarkers, Tumor
0
Types de publication
Journal Article
Meta-Analysis
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Faculty of Medicine and Health Sciences of Ghent University, Belgium
ID : AAP-bursery to L.W.
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